BACSU:PERR

Species (Taxon ID)	Bacillus subtilis (strain 168). (224308)
Gene Name(s)	perR (synonyms: ygaG)
Protein Name(s)	Peroxide operon regulator
External Links
UniProt	P71086
EMBL	Z82044 AL009126
PIR	B69816
RefSeq	NP_388753.1
PDB	2FE3 2RGV 3F8N
PDBsum	2FE3 2RGV 3F8N
ProteinModelPortal	P71086
SMR	P71086
STRING	224308.BSU08730
PaxDb	P71086
EnsemblBacteria	CAB12701
GeneID	939227
KEGG	bsu:BSU08730
PATRIC	18973398
GenoList	BSU08730
eggNOG	COG0735
HOGENOM	HOG000014143
InParanoid	P71086
KO	K09825
OMA	HVICEQC
OrthoDB	EOG6J48SS
PhylomeDB	P71086
BioCyc	BSUB:BSU08730-MONOMER
EvolutionaryTrace	P71086
Proteomes	UP000001570
GO	GO:0005737 GO:0003677 GO:0046872 GO:0003700 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR002481 IPR011991
Pfam	PF01475

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006979		PMID:21398634^[1]	ECO:0000315				Fig 2. graph A. Repressor activities in mutant vs wild type	complete
part_of	GO:0032993	protein-DNA complex	PMID:14563870^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:11532148^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:16166527^[4]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:14563870^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12180919^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:12029044^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:11532148^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:16166527^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:11532148^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:14563870^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:11532148^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:14563870^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:12180919^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:12029044^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:11532148^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:11532148^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:14563870^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:16166527^[4]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:14563870^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:16166527^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:14563870^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:11532148^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:16166527^[4]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:14563870^[2]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:12180919^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:12029044^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:11532148^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_000964.3	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:16166527^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:11532148^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1900376	regulation of secondary metabolite biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q9HT74	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10359 PANTHER:PTN002112386 UniProtKB:P0A0S8 UniProtKB:P0C6C8 UniProtKB:P54479 UniProtKB:P54574 UniProtKB:P74739 UniProtKB:P9WN85 UniProtKB:Q03456 UniProtKB:Q7BR72 UniProtKB:Q7CQY3 UniProtKB:Q8EFN3 UniProtKB:Q8PAL3 UniProtKB:Q8Y5U9 UniProtKB:Q9HT74 UniProtKB:Q9L2H5	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q03456	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10359 PANTHER:PTN002112386 UniProtKB:P9WN85	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:P9WN87	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q9HT74	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001216	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001216	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001216	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001216	P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002481	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002481	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ma, Z et al. (2011) Identification of altered function alleles that affect Bacillus subtilis PerR metal ion selectivity. Nucleic Acids Res. 39 5036-44 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Fuangthong, M & Helmann, JD (2003) Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis. J. Bacteriol. 185 6348-57 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Herbig, AF & Helmann, JD (2001) Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA. Mol. Microbiol. 41 849-59 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Hayashi, K et al. (2005) The H2O2 stress-responsive regulator PerR positively regulates srfA expression in Bacillus subtilis. J. Bacteriol. 187 6659-67 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaballa, A & Helmann, JD (2002) A peroxide-induced zinc uptake system plays an important role in protection against oxidative stress in Bacillus subtilis. Mol. Microbiol. 45 997-1005 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Fuangthong, M et al. (2002) Regulation of the Bacillus subtilis fur and perR genes by PerR: not all members of the PerR regulon are peroxide inducible. J. Bacteriol. 184 3276-86 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21398634-1] Ma, Z et al. (2011) Identification of altered function alleles that affect Bacillus subtilis PerR metal ion selectivity. Nucleic Acids Res. 39 5036-44 PubMed GONUTS page

[PMID:14563870-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Fuangthong, M & Helmann, JD (2003) Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis. J. Bacteriol. 185 6348-57 PubMed GONUTS page

[PMID:11532148-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Herbig, AF & Helmann, JD (2001) Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA. Mol. Microbiol. 41 849-59 PubMed GONUTS page

[PMID:16166527-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Hayashi, K et al. (2005) The H2O2 stress-responsive regulator PerR positively regulates srfA expression in Bacillus subtilis. J. Bacteriol. 187 6659-67 PubMed GONUTS page

[PMID:12180919-5] 5.0 ^5.1 ^5.2 Gaballa, A & Helmann, JD (2002) A peroxide-induced zinc uptake system plays an important role in protection against oxidative stress in Bacillus subtilis. Mol. Microbiol. 45 997-1005 PubMed GONUTS page

[PMID:12029044-6] 6.0 ^6.1 ^6.2 Fuangthong, M et al. (2002) Regulation of the Bacillus subtilis fur and perR genes by PerR: not all members of the PerR regulon are peroxide inducible. J. Bacteriol. 184 3276-86 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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BACSU:PERR

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