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BACSU:GLNA

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Species (Taxon ID) Bacillus subtilis (strain 168). (224308)
Gene Name(s) glnA
Protein Name(s) Glutamine synthetase

Glutamate--ammonia ligase

External Links
UniProt P12425
EMBL M22811
D00854
U66480
AL009126
PIR JT0392
RefSeq NP_389628.1
WP_003231737.1
PDB 2FWX
3QAJ
4LNF
4LNI
4LNK
4LNN
4LNO
PDBsum 2FWX
3QAJ
4LNF
4LNI
4LNK
4LNN
4LNO
ProteinModelPortal P12425
SMR P12425
DIP DIP-29670N
IntAct P12425
MINT MINT-224371
STRING 224308.BSU17460
PaxDb P12425
EnsemblBacteria CAB13630
GeneID 940020
KEGG bsu:BSU17460
PATRIC 18975307
GenoList BSU17460
eggNOG COG0174
HOGENOM HOG000005156
InParanoid P12425
KO K01915
OMA KVLNQVG
OrthoDB EOG6B360N
PhylomeDB P12425
BioCyc BSUB:BSU17460-MONOMER
SABIO-RK P12425
Proteomes UP000001570
GO GO:0005737
GO:0005524
GO:0004356
GO:0006542
GO:0009399
Gene3D 3.10.20.70
3.30.590.10
InterPro IPR008147
IPR014746
IPR008146
IPR027303
IPR004809
IPR001637
IPR027302
Pfam PF00120
PF03951
SUPFAM SSF54368
TIGRFAMs TIGR00653
PROSITE PS00180
PS00182
PS00181

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006542

glutamine biosynthetic process

PMID:8093698[1]

ECO:0000315

P

The strain, named CAR2, did not exhibit detectable GS activity, and we could not detect any GS antigen when we probed [35S]methionine-labeled extracts with antibody to GS (Fig. 2).

complete
CACAO 2812

involved_in

GO:0090295

nitrogen catabolite repression of transcription

PMID:11719184[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070406

glutamine binding

PMID:11719184[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:11719184[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q45666

F

Seeded From UniProt

complete

involved_in

GO:1904797

negative regulation of core promoter binding

PMID:11719184[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:11719184[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043562

cellular response to nitrogen levels

PMID:11719184[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006542

glutamine biosynthetic process

PMID:8093698[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001839150
UniProtKB:P12425

F

Seeded From UniProt

complete

involved_in

GO:0006598

polyamine catabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001839150
UniProtKB:Q9I3F1

P

Seeded From UniProt

complete

involved_in

GO:0006542

glutamine biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000751958
UniProtKB:P12425

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014746

F

Seeded From UniProt

complete

enables

GO:0004356

glutamate-ammonia ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004809
InterPro:IPR008146
InterPro:IPR008147
InterPro:IPR036651

F

Seeded From UniProt

complete

involved_in

GO:0006542

glutamine biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008147
InterPro:IPR036651

P

Seeded From UniProt

complete

involved_in

GO:0006807

nitrogen compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008146
InterPro:IPR008147
InterPro:IPR036651

P

Seeded From UniProt

complete

enables

GO:0004356

glutamate-ammonia ligase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.3.1.2

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Schreier, HJ et al. (1993) Altered regulation of the glnRA operon in a Bacillus subtilis mutant that produces methionine sulfoximine-tolerant glutamine synthetase. J. Bacteriol. 175 892-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Wray, LV Jr et al. (2001) Bacillus subtilis glutamine synthetase controls gene expression through a protein-protein interaction with transcription factor TnrA. Cell 107 427-35 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page