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BACSU:CLPP

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Species (Taxon ID) Bacillus subtilis (strain 168). (224308)
Gene Name(s) clpP (ECO:0000255 with HAMAP-Rule:MF_00444) (synonyms: yvdN)
Protein Name(s) ATP-dependent Clp protease proteolytic subunit (ECO:0000255 with HAMAP-Rule:MF_00444)

Caseinolytic protease Endopeptidase Clp (ECO:0000255 with HAMAP-Rule:MF_00444) Stress protein G7

External Links
UniProt P80244
EMBL U59754
Z94043
AL009126
PIR B69601
RefSeq NP_391334.1
PDB 3KTG
3KTH
3KTI
3KTJ
3KTK
3TT6
3TT7
PDBsum 3KTG
3KTH
3KTI
3KTJ
3KTK
3TT6
3TT7
ProteinModelPortal P80244
SMR P80244
DIP DIP-43711N
IntAct P80244
MINT MINT-2838977
STRING 224308.BSU34540
ChEMBL CHEMBL2146309
MEROPS S14.001
PaxDb P80244
PRIDE P80244
EnsemblBacteria CAB15459
GeneID 938625
KEGG bsu:BSU34540
PATRIC 18978912
GenoList BSU34540
eggNOG COG0740
HOGENOM HOG000285833
InParanoid P80244
KO K01358
OMA MEINLRE
OrthoDB EOG6Z3KQ0
PhylomeDB P80244
BioCyc BSUB:BSU34540-MONOMER
BRENDA 3.4.21.92
EvolutionaryTrace P80244
PRO PR:P80244
Proteomes UP000001570
GO GO:0005737
GO:0004176
GO:0004252
GO:0006200
Gene3D 3.90.226.10
HAMAP MF_00444
InterPro IPR001907
IPR029045
IPR023562
IPR018215
PANTHER PTHR10381
Pfam PF00574
PRINTS PR00127
SUPFAM SSF52096
TIGRFAMs TIGR00493
PROSITE PS00382
PS00381

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004176

ATP-dependent peptidase activity

PMID:14763982[1]

ECO:0000315

F

Figure 1a, 1b, 2, 3

complete
CACAO 2305

enables

GO:0004176

ATP-dependent peptidase activity

PMID:14763982[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051117

ATPase binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10158
PANTHER:PTN000043558

F

Seeded From UniProt

complete

part_of

GO:0009368

endopeptidase Clp complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000043558
TAIR:locus:2031070
TAIR:locus:2033344
TAIR:locus:2034625
TAIR:locus:2163538
TAIR:locus:2178282
TAIR:locus:2196120
UniProtKB:Q16740
UniProtKB:Q9SAA2

C

Seeded From UniProt

complete

involved_in

GO:0006515

protein quality control for misfolded or incompletely synthesized proteins

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10158
PANTHER:PTN000043558

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000043558
UniProtKB:Q16740
WB:WBGene00014172

F

Seeded From UniProt

complete

enables

GO:0004176

ATP-dependent peptidase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10158
PANTHER:PTN000043558
UniProtKB:P80244

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:20305655[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P80244

F

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001907

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001907

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000089051

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000089051

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000089051

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Kock, H et al. (2004) MurAA, catalysing the first committed step in peptidoglycan biosynthesis, is a target of Clp-dependent proteolysis in Bacillus subtilis. Mol. Microbiol. 51 1087-102 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. Lee, BG et al. (2010) Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat. Struct. Mol. Biol. 17 471-8 PubMed GONUTS page