ASFB7:IAP

Species (Taxon ID)	African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)(ASFV). (10498)
Gene Name(s)	No Information Provided.
Protein Name(s)	Inhibitor of apoptosis protein IAP
External Links
UniProt	P69180
EMBL	U18466
RefSeq	NP_042727.1
ProteinModelPortal	P69180
GeneID	1488798
Proteomes	UP000000624
GO	GO:0030430 GO:0046872 GO:0039652 GO:0039650
Gene3D	1.10.1170.10
InterPro	IPR010549 IPR001370
Pfam	PF06556 PF00653
SMART	SM00238
PROSITE	PS01282 PS50143

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0039650	suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process	PMID:11222676	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C		Seeded From UniProt	complete
	GO:0039650	suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process	PMID:11222676	ECO:0000314			P		As seen in Figure 5, viral IAP inhibits host cell apopotosis by modulating caspase-3 activity within the cell. This was determined by comparing the levels of caspase-3 activity in Vero cells infected with the deletion mutant ΔIAP and the parental virus BA71V, using a caspase-specific assay	complete CACAO 6395
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0039526	modulation by virus of host apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1119	P		Seeded From UniProt	complete
involved_in	GO:0039652	activation by virus of host NF-kappaB transcription factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1074	P		Seeded From UniProt	complete
involved_in	GO:0039650	suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1085	P		Seeded From UniProt	complete
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