ARATH:Q42512

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	cor15a (ECO:0000313 with EMBL:AAB87705.1)
Protein Name(s)	At2g42540/F14N22.19 (ECO:0000313 with EMBL:AAK63957.1) Cold-regulated protein 15a (ECO:0000313 with EMBL:AEC10136.1) Cold-regulated protein cor15a (ECO:0000313 with EMBL:AAD22999.1) Cor15 protein (ECO:0000313 with EMBL:CAA45499.1) Cor15a protein (ECO:0000313 with EMBL:AAB87705.1)
External Links
UniProt	Q42512
EMBL	U01377 AC007087 AY039853 AY057640 AY113048 CP002685 X64138
PIR	S43769
RefSeq	NP_181782.1
UniGene	At.20845
EnsemblPlants	AT2G42540.2
GeneID	818854
KEGG	ath:AT2G42540
TAIR	AT2G42540
eggNOG	NOG303515
HOGENOM	HOG000093206
OMA	HSGAKQS
PhylomeDB	Q42512
Proteomes	UP000006548
ExpressionAtlas	Q42512
Genevestigator	Q42512
GO	GO:0009507 GO:0009941 GO:0009570 GO:0009631 GO:0010150 GO:0050821 GO:0010017 GO:0009409 GO:0050826 GO:0006970

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0009631	cold acclimation	PMID:25096979^[1]	ECO:0000314			P	Figure 1 shows COR-15 shows silencing of cold acclimation which is stabilization of the chloroplast membranes.	complete CACAO 10344
involved_in	GO:0009416	response to light stimulus	PMID:21471455^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:21471455^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	AGI_LocusCode:AT2G46830	P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:21471455^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	AGI_LocusCode:AT2G46830	P	Seeded From UniProt	complete
involved_in	GO:0009737	response to abscisic acid	PMID:21673078^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005534	galactose binding	PMID:20510170^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010286	heat acclimation	PMID:18540080^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009819	drought recovery	PMID:18540080^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:20510170^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:18540080^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:17384167^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:17384167^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:17384167^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:17384167^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009570	chloroplast stroma	PMID:17384167^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009651	response to salt stress	PMID:9668134^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009737	response to abscisic acid	PMID:9668134^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:11038526^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009737	response to abscisic acid	PMID:8193295^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009414	response to water deprivation	PMID:8193295^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:8193295^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:16668917^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:16668917^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009570	chloroplast stroma	PMID:16668917^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009667	plastid inner membrane organization	PMID:9826741^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:9826741^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009414	response to water deprivation	PMID:12785063^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009644	response to high light intensity	PMID:12785063^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	PMID:12148528^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:12148528^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0061077	chaperone-mediated protein folding	PMID:18540080^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050826	response to freezing	PMID:1567390^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:18540080^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010150	leaf senescence	PMID:21673078^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010017	red or far-red light signaling pathway	PMID:17965713^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009941	chloroplast envelope	PMID:12938931^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:25096979^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:1567390^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009570	chloroplast stroma	PMID:20061580^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009570	chloroplast stroma	PMID:16207701^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	PMID:25005920^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	PMID:18431481^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	PMID:15028209^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:19563440^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:16258011^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	PMID:11779861^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	AGI_LocusCode:AT5G67030	P	Seeded From UniProt	complete
part_of	GO:0009536	plastid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0934	C	Seeded From UniProt	complete
part_of	GO:0009507	chloroplast	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0150	C	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
part_of	GO:0009570	chloroplast stroma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0055	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Thalhammer, A et al. (2014) Disordered cold regulated15 proteins protect chloroplast membranes during freezing through binding and folding, but do not stabilize chloroplast enzymes in vivo. Plant Physiol. 166 190-201 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Dong, MA et al. (2011) Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 108 7241-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Yang, SD et al. (2011) The Arabidopsis NAC transcription factor VNI2 integrates abscisic acid signals into leaf senescence via the COR/RD genes. Plant Cell 23 2155-68 PubMed GONUTS page
↑ ^4.0 ^4.1 Thalhammer, A et al. (2010) Interaction of two intrinsically disordered plant stress proteins (COR15A and COR15B) with lipid membranes in the dry state. Biochim. Biophys. Acta 1798 1812-20 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Nakayama, K et al. (2008) Evaluation of the protective activities of a late embryogenesis abundant (LEA) related protein, Cor15am, during various stresses in vitro. Biosci. Biotechnol. Biochem. 72 1642-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Nakayama, K et al. (2007) Arabidopsis Cor15am is a chloroplast stromal protein that has cryoprotective activity and forms oligomers. Plant Physiol. 144 513-23 PubMed GONUTS page
↑ ^7.0 ^7.1 Ishitani, M et al. (1998) HOS1, a genetic locus involved in cold-responsive gene expression in arabidopsis. Plant Cell 10 1151-61 PubMed GONUTS page
↑ Artus, NN et al. (1996) Constitutive expression of the cold-regulated Arabidopsis thaliana COR15a gene affects both chloroplast and protoplast freezing tolerance. Proc. Natl. Acad. Sci. U.S.A. 93 13404-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Baker, SS et al. (1994) The 5'-region of Arabidopsis thaliana cor15a has cis-acting elements that confer cold-, drought- and ABA-regulated gene expression. Plant Mol. Biol. 24 701-13 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Lin, C & Thomashow, MF (1992) DNA Sequence Analysis of a Complementary DNA for Cold-Regulated Arabidopsis Gene cor15 and Characterization of the COR 15 Polypeptide. Plant Physiol. 99 519-25 PubMed GONUTS page
↑ ^11.0 ^11.1 Steponkus, PL et al. (1998) Mode of action of the COR15a gene on the freezing tolerance of Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 95 14570-5 PubMed GONUTS page
↑ ^12.0 ^12.1 Kimura, M et al. (2003) Identification of Arabidopsis genes regulated by high light-stress using cDNA microarray. Photochem. Photobiol. 77 226-33 PubMed GONUTS page
↑ ^13.0 ^13.1 Kim, HJ et al. (2002) Light signalling mediated by phytochrome plays an important role in cold-induced gene expression through the C-repeat/dehydration responsive element (C/DRE) in Arabidopsis thaliana. Plant J. 29 693-704 PubMed GONUTS page
↑ ^14.0 ^14.1 Lin, C & Thomashow, MF (1992) A cold-regulated Arabidopsis gene encodes a polypeptide having potent cryoprotective activity. Biochem. Biophys. Res. Commun. 183 1103-8 PubMed GONUTS page
↑ Franklin, KA & Whitelam, GC (2007) Light-quality regulation of freezing tolerance in Arabidopsis thaliana. Nat. Genet. 39 1410-3 PubMed GONUTS page
↑ Froehlich, JE et al. () Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. J. Proteome Res. 2 413-25 PubMed GONUTS page
↑ Ferro, M et al. (2010) AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Mol. Cell Proteomics 9 1063-84 PubMed GONUTS page
↑ Peltier, JB et al. (2006) The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Mol. Cell Proteomics 5 114-33 PubMed GONUTS page
↑ Candat, A et al. (2014) The ubiquitous distribution of late embryogenesis abundant proteins across cell compartments in Arabidopsis offers tailored protection against abiotic stress. Plant Cell 26 3148-66 PubMed GONUTS page
↑ Zybailov, B et al. (2008) Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. PLoS ONE 3 e1994 PubMed GONUTS page
↑ Kleffmann, T et al. (2004) The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions. Curr. Biol. 14 354-62 PubMed GONUTS page
↑ Wang, Y & Hua, J (2009) A moderate decrease in temperature induces COR15a expression through the CBF signaling cascade and enhances freezing tolerance. Plant J. 60 340-9 PubMed GONUTS page
↑ Vergnolle, C et al. (2005) The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions. Plant Physiol. 139 1217-33 PubMed GONUTS page
↑ Xiong, L et al. (2002) Regulation of osmotic stress-responsive gene expression by the LOS6/ABA1 locus in Arabidopsis. J. Biol. Chem. 277 8588-96 PubMed GONUTS page

[PMID:25096979-1] 1.0 ^1.1 Thalhammer, A et al. (2014) Disordered cold regulated15 proteins protect chloroplast membranes during freezing through binding and folding, but do not stabilize chloroplast enzymes in vivo. Plant Physiol. 166 190-201 PubMed GONUTS page

[PMID:21471455-2] 2.0 ^2.1 ^2.2 Dong, MA et al. (2011) Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 108 7241-6 PubMed GONUTS page

[PMID:21673078-3] 3.0 ^3.1 Yang, SD et al. (2011) The Arabidopsis NAC transcription factor VNI2 integrates abscisic acid signals into leaf senescence via the COR/RD genes. Plant Cell 23 2155-68 PubMed GONUTS page

[PMID:20510170-4] 4.0 ^4.1 Thalhammer, A et al. (2010) Interaction of two intrinsically disordered plant stress proteins (COR15A and COR15B) with lipid membranes in the dry state. Biochim. Biophys. Acta 1798 1812-20 PubMed GONUTS page

[PMID:18540080-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Nakayama, K et al. (2008) Evaluation of the protective activities of a late embryogenesis abundant (LEA) related protein, Cor15am, during various stresses in vitro. Biosci. Biotechnol. Biochem. 72 1642-5 PubMed GONUTS page

[PMID:17384167-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Nakayama, K et al. (2007) Arabidopsis Cor15am is a chloroplast stromal protein that has cryoprotective activity and forms oligomers. Plant Physiol. 144 513-23 PubMed GONUTS page

[PMID:9668134-7] 7.0 ^7.1 Ishitani, M et al. (1998) HOS1, a genetic locus involved in cold-responsive gene expression in arabidopsis. Plant Cell 10 1151-61 PubMed GONUTS page

[PMID:11038526-8] Artus, NN et al. (1996) Constitutive expression of the cold-regulated Arabidopsis thaliana COR15a gene affects both chloroplast and protoplast freezing tolerance. Proc. Natl. Acad. Sci. U.S.A. 93 13404-9 PubMed GONUTS page

[PMID:8193295-9] 9.0 ^9.1 ^9.2 Baker, SS et al. (1994) The 5'-region of Arabidopsis thaliana cor15a has cis-acting elements that confer cold-, drought- and ABA-regulated gene expression. Plant Mol. Biol. 24 701-13 PubMed GONUTS page

[PMID:16668917-10] 10.0 ^10.1 ^10.2 Lin, C & Thomashow, MF (1992) DNA Sequence Analysis of a Complementary DNA for Cold-Regulated Arabidopsis Gene cor15 and Characterization of the COR 15 Polypeptide. Plant Physiol. 99 519-25 PubMed GONUTS page

[PMID:9826741-11] 11.0 ^11.1 Steponkus, PL et al. (1998) Mode of action of the COR15a gene on the freezing tolerance of Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 95 14570-5 PubMed GONUTS page

[PMID:12785063-12] 12.0 ^12.1 Kimura, M et al. (2003) Identification of Arabidopsis genes regulated by high light-stress using cDNA microarray. Photochem. Photobiol. 77 226-33 PubMed GONUTS page

[PMID:12148528-13] 13.0 ^13.1 Kim, HJ et al. (2002) Light signalling mediated by phytochrome plays an important role in cold-induced gene expression through the C-repeat/dehydration responsive element (C/DRE) in Arabidopsis thaliana. Plant J. 29 693-704 PubMed GONUTS page

[PMID:1567390-14] 14.0 ^14.1 Lin, C & Thomashow, MF (1992) A cold-regulated Arabidopsis gene encodes a polypeptide having potent cryoprotective activity. Biochem. Biophys. Res. Commun. 183 1103-8 PubMed GONUTS page

[PMID:17965713-15] Franklin, KA & Whitelam, GC (2007) Light-quality regulation of freezing tolerance in Arabidopsis thaliana. Nat. Genet. 39 1410-3 PubMed GONUTS page

[PMID:12938931-16] Froehlich, JE et al. () Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. J. Proteome Res. 2 413-25 PubMed GONUTS page

[PMID:20061580-17] Ferro, M et al. (2010) AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Mol. Cell Proteomics 9 1063-84 PubMed GONUTS page

[PMID:16207701-18] Peltier, JB et al. (2006) The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Mol. Cell Proteomics 5 114-33 PubMed GONUTS page

[PMID:25005920-19] Candat, A et al. (2014) The ubiquitous distribution of late embryogenesis abundant proteins across cell compartments in Arabidopsis offers tailored protection against abiotic stress. Plant Cell 26 3148-66 PubMed GONUTS page

[PMID:18431481-20] Zybailov, B et al. (2008) Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. PLoS ONE 3 e1994 PubMed GONUTS page

[PMID:15028209-21] Kleffmann, T et al. (2004) The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions. Curr. Biol. 14 354-62 PubMed GONUTS page

[PMID:19563440-22] Wang, Y & Hua, J (2009) A moderate decrease in temperature induces COR15a expression through the CBF signaling cascade and enhances freezing tolerance. Plant J. 60 340-9 PubMed GONUTS page

[PMID:16258011-23] Vergnolle, C et al. (2005) The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions. Plant Physiol. 139 1217-33 PubMed GONUTS page

[PMID:11779861-24] Xiong, L et al. (2002) Regulation of osmotic stress-responsive gene expression by the LOS6/ABA1 locus in Arabidopsis. J. Biol. Chem. 277 8588-96 PubMed GONUTS page

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ARATH:Q42512

Contents

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References

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