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ARATH:NHX2

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) NHX2
Protein Name(s) Sodium/hydrogen exchanger 2

Na(+)/H(+) exchanger 2 NHE-2

External Links
UniProt Q56XP4
EMBL AF490586
AC009465
CP002686
CP002686
AK221629
RefSeq NP_001078110.1
NP_187154.1
UniGene At.40740
ProteinModelPortal Q56XP4
SMR Q56XP4
STRING 3702.AT3G05030.1-P
PaxDb Q56XP4
PRIDE Q56XP4
EnsemblPlants AT3G05030.1
GeneID 819665
KEGG ath:AT3G05030
TAIR AT3G05030
eggNOG COG0025
HOGENOM HOG000272718
InParanoid Q56XP4
OMA KQQVVIW
PhylomeDB Q56XP4
Reactome REACT_239120
Proteomes UP000006548
Genevestigator Q56XP4
GO GO:0016021
GO:0005774
GO:0015386
GO:0015385
GO:0055075
GO:0010107
GO:0006885
GO:0090333
GO:0035725
InterPro IPR006153
IPR018422
IPR029872
IPR004709
PANTHER PTHR10110
PTHR10110:SF101
Pfam PF00999
PRINTS PR01084
TIGRFAMs TIGR00840

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0090333

regulation of stomatal closure

PMID:22438021[1]

ECO:0000316

genetic interaction evidence used in manual assertion

AGI_LocusCode:AT5G27150

P

Seeded From UniProt

complete

involved_in

GO:0055075

potassium ion homeostasis

PMID:22438021[1]

ECO:0000316

genetic interaction evidence used in manual assertion

AGI_LocusCode:AT5G27150

P

Seeded From UniProt

complete

enables

GO:0015386

potassium:proton antiporter activity

PMID:22438021[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015385

sodium:proton antiporter activity

PMID:22438021[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0098719

sodium ion import across plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000011605
UniProtKB:P19634
UniProtKB:P48764

P

Seeded From UniProt

complete

involved_in

GO:0090333

regulation of stomatal closure

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001603945
TAIR:locus:2114810
TAIR:locus:2181246

P

Seeded From UniProt

complete

involved_in

GO:0071805

potassium ion transmembrane transport

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000011605
SGD:S000002864
TAIR:locus:2041100

P

Seeded From UniProt

complete

involved_in

GO:0051453

regulation of intracellular pH

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1924281
PANTHER:PTN000011605
RGD:3718
UniProtKB:P19634
dictyBase:DDB_G0275711

P

Seeded From UniProt

complete

enables

GO:0015386

potassium:proton antiporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1924281
PANTHER:PTN000011605
SGD:S000002864
TAIR:locus:2114810
UniProtKB:Q96T83

F

Seeded From UniProt

complete

enables

GO:0015385

sodium:proton antiporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102462
MGI:MGI:105064
MGI:MGI:105075
MGI:MGI:1924281
PANTHER:PTN000011605
RGD:3718
RGD:3719
RGD:3720
RGD:620473
SGD:S000002864
TAIR:locus:2114810
TAIR:locus:2173972
TAIR:locus:2181246
UniProtKB:P19634
UniProtKB:P48764
UniProtKB:Q96T83
WB:WBGene00003730

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11940
MGI:MGI:105064
MGI:MGI:2443511
PANTHER:PTN000011605
RGD:3718
TAIR:locus:2041100
TAIR:locus:2173972
TAIR:locus:2181246
UniProtKB:P19634
UniProtKB:P48764
UniProtKB:Q3YL57
UniProtKB:Q92581

C

Seeded From UniProt

complete

involved_in

GO:1902600

proton transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015299

P

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029872

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029872

C

Seeded From UniProt

complete

involved_in

GO:0006812

cation transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006153
InterPro:IPR018422

P

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004709
InterPro:IPR029872

P

Seeded From UniProt

complete

involved_in

GO:0006885

regulation of pH

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004709

P

Seeded From UniProt

complete

involved_in

GO:0009651

response to salt stress

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029872

P

Seeded From UniProt

complete

enables

GO:0015299

solute:proton antiporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006153
InterPro:IPR018422

F

Seeded From UniProt

complete

enables

GO:0015385

sodium:proton antiporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004709

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004709
InterPro:IPR006153
InterPro:IPR018422

C

Seeded From UniProt

complete

involved_in

GO:0055075

potassium ion homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029872

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004709
InterPro:IPR006153

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

enables

GO:0015297

antiporter activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0050

F

Seeded From UniProt

complete

part_of

GO:0005773

vacuole

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0926

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0739

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Barragán, V et al. (2012) Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis. Plant Cell 24 1127-42 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page