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ARATH:MYST1

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) HAM1 (ECO:0000303 with PMID:17877703[1]) (synonyms: HAG4 (ECO:0000303 with PMID:12466527[2]))
Protein Name(s) Histone acetyltransferase of the MYST family 1 (ECO:0000303 with PMID:17877703[1])

Histone acetyltransferase of the GNAT/MYST superfamily 4 (ECO:0000303 with PMID:12466527[2]) MYST-like histone acetyltransferase 1 (ECO:0000303 with PMID:17877703[1])

External Links
UniProt Q9FLF7
EMBL AB010076
CP002688
AY099684
BT000277
AB493812
RefSeq NP_201266.1
UniGene At.28949
At.49220
ProteinModelPortal Q9FLF7
SMR Q9FLF7
BioGrid 21824
IntAct Q9FLF7
STRING 3702.AT5G64610.1
PaxDb Q9FLF7
PRIDE Q9FLF7
EnsemblPlants [example_ID AT5G64610.1]
GeneID 836582
Gramene AT5G64610.1
KEGG ath:AT5G64610
TAIR AT5G64610
eggNOG KOG2747
COG5027
HOGENOM HOG000182457
InParanoid Q9FLF7
KO K11308
OMA WTRILLD
PhylomeDB Q9FLF7
BioCyc ARA:AT5G64610-MONOMER
BRENDA 2.3.1.48
Reactome [www.reactome.org/content/detail/R-ATH-2559586 R-ATH-2559586]
[www.reactome.org/content/detail/R-ATH-3214847 R-ATH-3214847]
[www.reactome.org/content/detail/R-ATH-5693548 R-ATH-5693548]
[www.reactome.org/content/detail/R-ATH-5693565 R-ATH-5693565]
PRO PR:Q9FLF7
Proteomes UP000006548
Genevisible Q9FLF7
GO GO:0005634
GO:0004402
GO:0043995
GO:0046872
GO:0006281
GO:0016573
GO:0043981
GO:2000028
GO:0006355
GO:0010224
GO:0006351
Gene3D 3.40.630.30
InterPro IPR016181
IPR000953
IPR016197
IPR002717
IPR025995
Pfam PF01853
PF11717
SMART SM00298
SUPFAM SSF54160
SSF55729
PROSITE PS51726

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:2000028

regulation of photoperiodism, flowering

PMID:23273925[3]

ECO:0000315

P

Figure 1C shows that amiRNA-HAM1 (HAM1 knockdown) lines grew normally as the wild-type Col in the vegetative stage, but flowered earlier than Col under both LD and SD conditions.

Figure 3B demonstrates that HAM1-overexpressing transgenic plants (HAM1-OE) displayed a delayed flowering time phenotype compared to wild type, suggesting that HAM1 is a negative regulator of flowering.

complete
CACAO 8182

GO:0043995

histone acetyltransferase activity (H4-K5 specific)

PMID:23273925[3]

ECO:0000315

F

Figure 5A shows a Western blot analysis in amiRNA-HAM1 (HAM1 knockdown) lines compared to wildtype that demonstrates a significant decrease in global H4K5 acetylation. In contrast, H4K5 acetylation was significantly increased in HAM1-OE (over-expressed) lines.

complete
CACAO 8183

enables

GO:0043995

histone acetyltransferase activity (H4-K5 specific)

PMID:23273925[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000028

regulation of photoperiodism, flowering

PMID:23273925[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010224

response to UV-B

PMID:22170978[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:22170978[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17877703[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004402

histone acetyltransferase activity

PMID:17877703[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028387
MGI:MGI:1932051
PANTHER:PTN000064894
RGD:1566399
RGD:621061
UniProtKB:O95251
UniProtKB:Q92993

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0087008
PANTHER:PTN000064894
UniProtKB:Q8WYB5
UniProtKB:Q92794
UniProtKB:Q92993
UniProtKB:Q96T23
UniProtKB:Q9H7Z6
WB:WBGene00007029

P

Seeded From UniProt

complete

enables

GO:0042393

histone binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000064894
UniProtKB:Q96T23

F

Seeded From UniProt

complete

enables

GO:0010485

H4 histone acetyltransferase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028387
PANTHER:PTN002239249
SGD:S000005770

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0014340
FB:FBgn0026080
FB:FBgn0026577
FB:FBgn0028387
FB:FBgn0087008
MGI:MGI:109529
MGI:MGI:2442415
PANTHER:PTN000064894
RGD:1304892
RGD:1566399
RGD:621061
TAIR:locus:2144776
TAIR:locus:2144841
TAIR:locus:2169779
TAIR:locus:2174764
UniProtKB:O95251
UniProtKB:Q6ZJM9
UniProtKB:Q8III2
UniProtKB:Q8WUB8
UniProtKB:Q92794
UniProtKB:Q92993
UniProtKB:Q96T23
UniProtKB:Q9H7Z6

C

Seeded From UniProt

complete

enables

GO:0004402

histone acetyltransferase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0014340
FB:FBgn0026080
MGI:MGI:1858746
PANTHER:PTN000064894
SGD:S000000148
SGD:S000004734
SGD:S000005770
TAIR:locus:2144776
TAIR:locus:2174764
UniProtKB:Q8III2
UniProtKB:Q8WYB5
UniProtKB:Q92794
UniProtKB:Q92993
UniProtKB:Q9H7Z6
ZFIN:ZDB-GENE-021022-3

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000064894
PomBase:SPAC17G8.13c
RGD:621061
SGD:S000004734
SGD:S000005770
ZFIN:ZDB-GENE-021022-3

C

Seeded From UniProt

complete

part_of

GO:0000123

histone acetyltransferase complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026080
PANTHER:PTN000064894
UniProtKB:O95251
UniProtKB:Q9H7Z6

C

Seeded From UniProt

complete

involved_in

GO:0043967

histone H4 acetylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0010485

P

Seeded From UniProt

complete

involved_in

GO:0043981

histone H4-K5 acetylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0043995

P

Seeded From UniProt

complete

enables

GO:0004402

histone acetyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002717

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002717

P

Seeded From UniProt

complete

involved_in

GO:0016573

histone acetylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002717

P

Seeded From UniProt

complete

enables

GO:0004402

histone acetyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.48

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Earley, KW et al. (2007) In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation. Plant J. 52 615-26 PubMed GONUTS page
  2. ↑ 2.0 2.1 Pandey, R et al. (2002) Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Nucleic Acids Res. 30 5036-55 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Xiao, J et al. (2013) Requirement of histone acetyltransferases HAM1 and HAM2 for epigenetic modification of FLC in regulating flowering in Arabidopsis. J. Plant Physiol. 170 444-51 PubMed GONUTS page
  4. ↑ 4.0 4.1 Campi, M et al. (2012) Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA. Plant Physiol. 158 981-95 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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