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ARATH:HFA4A

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) HSFA4A (synonyms: HSF15, HSF21)
Protein Name(s) Heat stress transcription factor A-4a

AtHsfA4a AtHsf-15 Heat shock factor protein 21 HSF 21 Heat shock transcription factor 21 HSTF 21

External Links
UniProt O49403
EMBL AL021711
AL161549
CP002687
AY125512
BT001049
U68561
PIR T05025
RefSeq NP_193623.1
UniGene At.1951
ProteinModelPortal O49403
SMR O49403
STRING 3702.AT4G18880.1-P
PaxDb O49403
PRIDE O49403
EnsemblPlants AT4G18880.1
GeneID 827622
KEGG ath:AT4G18880
GeneFarm 4104
TAIR AT4G18880
eggNOG COG5169
HOGENOM HOG000237979
InParanoid O49403
KO K09419
OMA GTATHEA
PhylomeDB O49403
Reactome REACT_220111
REACT_240287
REACT_249954
REACT_257743
Proteomes UP000006548
Genevestigator O49403
GO GO:0005737
GO:0005634
GO:0043565
GO:0003700
GO:0010200
GO:0009408
GO:0006351
Gene3D 1.10.10.10
InterPro IPR000232
IPR027725
IPR027709
IPR011991
PANTHER PTHR10015
PTHR10015:SF146
Pfam PF00447
PRINTS PR00056
SMART SM00415

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042538

hyperosmotic salinity response

PMID:24676858[1]

ECO:0000315

P

Figure 2 has an overexpressor mutant of HSFA4A compared to wild type Arabidopsis thaliana grown in high NaCl media conditions. Overexpressng plants had higher rates of survival, root, and rosette growth in comparison to wild type. Figure 4 shows the growth of a HSFA4A t-DNA knockout mutant grown on high salinity media compared to wild type. The HSFA4A knockout had lower rates of survival and smaller rosette size when compared to wild type. Complementation of the HSFA4A gene had a partial restoration of function seen in larger rosettes and higher survival rates with high concentrations of NaCl.

complete
CACAO 9700

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:24676858[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:24676858[1]

ECO:0000353

physical interaction evidence used in manual assertion

AGI_LocusCode:AT4G18880

F

Seeded From UniProt

complete

involved_in

GO:0010200

response to chitin

PMID:17722694[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:24676858[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24676858[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11118137[3]

ECO:0000250

sequence similarity evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0000302

response to reactive oxygen species

PMID:24676858[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061408

positive regulation of transcription from RNA polymerase II promoter in response to heat stress

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000001154
UniProtKB:Q00613

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001222
MGI:MGI:1347058
MGI:MGI:3045337
MGI:MGI:96238
MGI:MGI:96239
PANTHER:PTN000001154
RGD:1310808
SGD:S000005666
UniProtKB:P38529
UniProtKB:P38531
UniProtKB:Q00613
ZFIN:ZDB-GENE-000616-16
ZFIN:ZDB-GENE-011128-1
ZFIN:ZDB-GENE-050306-18

F

Seeded From UniProt

complete

involved_in

GO:0034605

cellular response to heat

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3045337
PANTHER:PTN000001154
RGD:620913
UniProtKB:O80982
UniProtKB:P38529
UniProtKB:P38531
UniProtKB:Q00613

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000195882
FB:FBgn0001222
MGI:MGI:3045337
MGI:MGI:96238
MGI:MGI:96239
PANTHER:PTN000001154
PomBase:SPAC2E12.02
PomBase:SPAC8C9.14
RGD:1310808
RGD:620913
SGD:S000001249
SGD:S000003041
SGD:S000005666
TAIR:locus:2005495
TAIR:locus:2075447
TAIR:locus:2117139
TAIR:locus:2144603
TAIR:locus:2149050
UniProtKB:I1LGH5
UniProtKB:I1MPZ9
UniProtKB:K7LH36
UniProtKB:O80982
UniProtKB:P38529
UniProtKB:P38530
UniProtKB:P38531
UniProtKB:Q00613
UniProtKB:Q43457
UniProtKB:Q5A287
UniProtKB:Q942D6
UniProtKB:Q9UBD0
WB:WBGene00002004

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000195882
FB:FBgn0001222
PANTHER:PTN000001154
SGD:S000001249
SGD:S000003041
TAIR:locus:2149050

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96238
MGI:MGI:96239
PANTHER:PTN000001154
PomBase:SPAC2E12.02
PomBase:SPAC8C9.14
SGD:S000005666
UniProtKB:Q00613

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000232

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000232

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000232

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000232

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Pérez-Salamó, I et al. (2014) The heat shock factor A4A confers salt tolerance and is regulated by oxidative stress and the mitogen-activated protein kinases MPK3 and MPK6. Plant Physiol. 165 319-34 PubMed GONUTS page
  2. Libault, M et al. (2007) Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor. Mol. Plant Microbe Interact. 20 900-11 PubMed GONUTS page
  3. Riechmann, JL et al. (2000) Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science 290 2105-10 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page