ARATH:GATP

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	POP2 (synonyms: GABA-T, HER1)
Protein Name(s)	Gamma-aminobutyrate transaminase POP2, mitochondrial AtGABA-T Protein HEXENAL RESPONSE 1 Protein POLLEN-PISTIL INCOMPATIBILITY 2 AtPOP2
External Links
UniProt	Q94CE5
EMBL	AF351125 AY034923 AY142571 AP001306 CP002686 CP002686 AK317625
RefSeq	NP_001189947.1 NP_566700.1
UniGene	At.22661 At.48693
ProteinModelPortal	Q94CE5
SMR	Q94CE5
STRING	3702.AT3G22200.1-P
PRIDE	Q94CE5
EnsemblPlants	AT3G22200.1
GeneID	821784
KEGG	ath:AT3G22200
TAIR	AT3G22200
eggNOG	COG0161
HOGENOM	HOG000020207
KO	K16871
OMA	VWSYAHP
PhylomeDB	Q94CE5
BioCyc	ARA:GQT-659-MONOMER MetaCyc:AT3G22200-LER-MONOMER
Proteomes	UP000006548
Genevestigator	Q94CE5
GO	GO:0005739 GO:0030170 GO:0008483
Gene3D	3.40.640.10 3.90.1150.10
InterPro	IPR005814 IPR015424 IPR015421 IPR015422
PANTHER	PTHR11986
Pfam	PF00202
PIRSF	PIRSF000521
SUPFAM	SSF53383
PROSITE	PS00600

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0003867	4-aminobutyrate transaminase activity	PMID:12859897^[1]	ECO:0000315			F	Table 1. In mutant pop2, GABA elevated 100-fold. GABA transaminases convert GABA to succinic semialdehyde and oxidized to succinic acid. In pop2 mutants the succinic acid levels are unchanged.	complete CACAO 2574
involved_in	GO:0048366	leaf development	PMID:21690177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009943	adaxial/abaxial axis specification	PMID:21690177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003867	4-aminobutyrate transaminase activity	PMID:12859897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0050897	cobalt ion binding	PMID:20018591^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048367	shoot system development	PMID:17971036^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048364	root development	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	PMID:16502469^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019484	beta-alanine catabolic process	PMID:12859897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010183	pollen tube guidance	PMID:12859897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010154	fruit development	PMID:17971036^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:17971036^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009865	pollen tube adhesion	PMID:8929415^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009860	pollen tube growth	PMID:12859897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009651	response to salt stress	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009450	gamma-aminobutyric acid catabolic process	PMID:12859897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009448	gamma-aminobutyric acid metabolic process	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:20018591^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:12492832^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006540	glutamate decarboxylation to succinate	PMID:12859897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006536	glutamate metabolic process	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006105	succinate metabolic process	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006020	inositol metabolic process	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0005985	sucrose metabolic process	PMID:23148892^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|part_of	GO:0005829	cytosol	PMID:21166475^[9]	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:22430844^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005774	vacuolar membrane	PMID:17151019^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22923678^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14671022^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12492832^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009448	gamma-aminobutyric acid metabolic process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002448348 TAIR:locus:2090414 UniProtKB:Q84P53 UniProtKB:Q84P54	P	Seeded From UniProt	complete
involved_in	GO:0009102	biotin biosynthetic process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10117 PANTHER:PTN000241343 SGD:S000005341 TAIR:locus:2174532 UniProtKB:P9WQ81 UniProtKB:Q4WD65 UniProtKB:Q5AYI6	P	Seeded From UniProt	complete
enables	GO:0004015	adenosylmethionine-8-amino-7-oxononanoate transaminase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10117 PANTHER:PTN000241343 SGD:S000005341 TAIR:locus:2174532 UniProtKB:P9WQ81	F	Seeded From UniProt	complete
enables	GO:0003867	4-aminobutyrate transaminase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002448348 TAIR:locus:2090414 UniProtKB:Q84P53 UniProtKB:Q84P54	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015421 InterPro:IPR015422	F	Seeded From UniProt	complete
enables	GO:0008483	transaminase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005814	F	Seeded From UniProt	complete
enables	GO:0030170	pyridoxal phosphate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005814	F	Seeded From UniProt	complete
enables	GO:0102351	gamma-aminobutyrate transaminase (glyoxylate dependent) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.6.1.96	F	Seeded From UniProt	complete
enables	GO:0034387	4-aminobutyrate:pyruvate transaminase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.6.1.96	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
enables	GO:0008483	transaminase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0032	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Palanivelu, R et al. (2003) Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels. Cell 114 47-59 PubMed GONUTS page
↑ ^2.0 ^2.1 Toyokura, K et al. (2011) Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis. Plant Cell Physiol. 52 1340-53 PubMed GONUTS page
↑ ^3.0 ^3.1 Tan, YF et al. (2010) Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Plant Physiol. 152 747-61 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Mirabella, R et al. (2008) The Arabidopsis her1 mutant implicates GABA in E-2-hexenal responsiveness. Plant J. 53 197-213 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Renault, H et al. (2013) γ-Aminobutyric acid transaminase deficiency impairs central carbon metabolism and leads to cell wall defects during salt stress in Arabidopsis roots. Plant Cell Environ. 36 1009-18 PubMed GONUTS page
↑ Sarry, JE et al. (2006) The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses. Proteomics 6 2180-98 PubMed GONUTS page
↑ Wilhelmi, LK & Preuss, D (1996) Self-sterility in Arabidopsis due to defective pollen tube guidance. Science 274 1535-7 PubMed GONUTS page
↑ ^8.0 ^8.1 Sweetlove, LJ et al. (2002) The impact of oxidative stress on Arabidopsis mitochondria. Plant J. 32 891-904 PubMed GONUTS page
↑ Ito, J et al. (2011) Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J. Proteome Res. 10 1571-82 PubMed GONUTS page
↑ Parsons, HT et al. (2012) Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Plant Physiol. 159 12-26 PubMed GONUTS page
↑ Jaquinod, M et al. (2007) A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Mol. Cell Proteomics 6 394-412 PubMed GONUTS page
↑ Nikolovski, N et al. (2012) Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Plant Physiol. 160 1037-51 PubMed GONUTS page
↑ Heazlewood, JL et al. (2004) Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Plant Cell 16 241-56 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12859897-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Palanivelu, R et al. (2003) Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels. Cell 114 47-59 PubMed GONUTS page

[PMID:21690177-2] 2.0 ^2.1 Toyokura, K et al. (2011) Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis. Plant Cell Physiol. 52 1340-53 PubMed GONUTS page

[PMID:20018591-3] 3.0 ^3.1 Tan, YF et al. (2010) Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Plant Physiol. 152 747-61 PubMed GONUTS page

[PMID:17971036-4] 4.0 ^4.1 ^4.2 Mirabella, R et al. (2008) The Arabidopsis her1 mutant implicates GABA in E-2-hexenal responsiveness. Plant J. 53 197-213 PubMed GONUTS page

[PMID:23148892-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Renault, H et al. (2013) γ-Aminobutyric acid transaminase deficiency impairs central carbon metabolism and leads to cell wall defects during salt stress in Arabidopsis roots. Plant Cell Environ. 36 1009-18 PubMed GONUTS page

[PMID:16502469-6] Sarry, JE et al. (2006) The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses. Proteomics 6 2180-98 PubMed GONUTS page

[PMID:8929415-7] Wilhelmi, LK & Preuss, D (1996) Self-sterility in Arabidopsis due to defective pollen tube guidance. Science 274 1535-7 PubMed GONUTS page

[PMID:12492832-8] 8.0 ^8.1 Sweetlove, LJ et al. (2002) The impact of oxidative stress on Arabidopsis mitochondria. Plant J. 32 891-904 PubMed GONUTS page

[PMID:21166475-9] Ito, J et al. (2011) Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J. Proteome Res. 10 1571-82 PubMed GONUTS page

[PMID:22430844-10] Parsons, HT et al. (2012) Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Plant Physiol. 159 12-26 PubMed GONUTS page

[PMID:17151019-11] Jaquinod, M et al. (2007) A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Mol. Cell Proteomics 6 394-412 PubMed GONUTS page

[PMID:22923678-12] Nikolovski, N et al. (2012) Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Plant Physiol. 160 1037-51 PubMed GONUTS page

[PMID:14671022-13] Heazlewood, JL et al. (2004) Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Plant Cell 16 241-56 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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ARATH:GATP

Contents

Annotations

Notes

References

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