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ARATH:CESA8

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) CESA8 (synonyms: IRX1, LEW2)
Protein Name(s) Cellulose synthase A catalytic subunit 8 [UDP-forming]

AtCesA8 Protein IRREGULAR XYLEM 1 AtIRX1 Protein LEAF WILTING 2

External Links
UniProt Q8LPK5
EMBL AF267742
AL035526
AL161549
CP002687
AY099636
PIR T04870
RefSeq NP_567564.1
UniGene At.66621
At.68239
ProteinModelPortal Q8LPK5
SMR Q8LPK5
BioGrid 12905
IntAct Q8LPK5
MINT MINT-6950961
CAZy GT2
PaxDb Q8LPK5
PRIDE Q8LPK5
EnsemblPlants AT4G18780.1
GeneID 827612
KEGG ath:AT4G18780
GeneFarm 5091
TAIR AT4G18780
eggNOG COG1215
HOGENOM HOG000241942
InParanoid Q8LPK5
KO K10999
OMA ICNICGE
PhylomeDB Q8LPK5
BioCyc MetaCyc:MONOMER-2366
UniPathway UPA00695
Proteomes UP000006548
Genevestigator Q8LPK5
GO GO:0005618
GO:0016021
GO:0005886
GO:0016760
GO:0046872
GO:0071555
GO:0030244
GO:0042742
GO:0050832
GO:0010116
GO:0006970
GO:0009414
GO:0009834
Gene3D 3.30.40.10
InterPro IPR005150
IPR027934
IPR029044
IPR013083
Pfam PF03552
PF14569
SUPFAM SSF53448

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016760

cellulose synthase (UDP-forming) activity

PMID:9165747[1]

ECO:0000315

F

CesA8 mutants have a reduced cellulose content and resulting irregular xylem shape. This suggests that this cellulose synthase isoform is involved in secondary wall synthesis of Arabidopsis thaliana.Fig. 6 demonstrates the results through electron microscopy of thinned cellular walls in mutants.Fig. 7 also illustrates how mutants (irx is synonym for CesA8) are weaker/more susceptible to bending.

complete
CACAO 4581

enables

GO:0016760

cellulose synthase (UDP-forming) activity

PMID:9165747[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|involved_in

GO:0052386

cell wall thickening

PMID:20377682[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050832

defense response to fungus

PMID:17351116[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:17351116[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030244

cellulose biosynthetic process

PMID:9165747[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009834

plant-type secondary cell wall biogenesis

PMID:9165747[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009414

response to water deprivation

PMID:15998313[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006970

response to osmotic stress

PMID:15998313[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:15593128[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030244

cellulose biosynthetic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000999295
TAIR:locus:2124167
TAIR:locus:2127776
TAIR:locus:2136308
TAIR:locus:2156789
TAIR:locus:2172457
TAIR:locus:2176090
TAIR:locus:2178193
TAIR:locus:2178935
UniProtKB:Q5JN63
UniProtKB:Q69P51
UniProtKB:Q9AV71

P

Seeded From UniProt

complete

enables

GO:0016759

cellulose synthase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000999295
TAIR:locus:2124167
TAIR:locus:2136308
TAIR:locus:2156789
TAIR:locus:2178935

F

Seeded From UniProt

complete

involved_in

GO:0009833

plant-type primary cell wall biogenesis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001410221
TAIR:locus:2127776
TAIR:locus:2156789
TAIR:locus:2176090

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001410221
TAIR:locus:2012050
TAIR:locus:2052576
TAIR:locus:2097700
TAIR:locus:2127776
TAIR:locus:2136308
TAIR:locus:2148171
TAIR:locus:2156789
TAIR:locus:2176090
TAIR:locus:2178193
TAIR:locus:2178935

C

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001410221
TAIR:locus:2097700
TAIR:locus:2127776
TAIR:locus:2148171
TAIR:locus:2156789

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001410221
TAIR:locus:2024745
TAIR:locus:2097700
TAIR:locus:2121080
TAIR:locus:2127776
TAIR:locus:2148171
TAIR:locus:2156789
TAIR:locus:2176090
UniProtKB:Q2QNS6

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005150

C

Seeded From UniProt

complete

enables

GO:0016760

cellulose synthase (UDP-forming) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005150

F

Seeded From UniProt

complete

involved_in

GO:0030244

cellulose biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005150

P

Seeded From UniProt

complete

enables

GO:0016760

cellulose synthase (UDP-forming) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.12

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

involved_in

GO:0030244

cellulose biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0135

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Turner, SR & Somerville, CR (1997) Collapsed xylem phenotype of Arabidopsis identifies mutants deficient in cellulose deposition in the secondary cell wall. Plant Cell 9 689-701 PubMed GONUTS page
  2. Betancur, L et al. (2010) Phylogenetically distinct cellulose synthase genes support secondary wall thickening in arabidopsis shoot trichomes and cotton fiber. J Integr Plant Biol 52 205-20 PubMed GONUTS page
  3. 3.0 3.1 Hernández-Blanco, C et al. (2007) Impairment of cellulose synthases required for Arabidopsis secondary cell wall formation enhances disease resistance. Plant Cell 19 890-903 PubMed GONUTS page
  4. 4.0 4.1 Chen, Z et al. (2005) Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J. 43 273-83 PubMed GONUTS page
  5. Boudart, G et al. (2005) Cell wall proteins in apoplastic fluids of Arabidopsis thaliana rosettes: identification by mass spectrometry and bioinformatics. Proteomics 5 212-21 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page