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ALIFS:LUXR

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Species (Taxon ID) Aliivibrio fischeri (Vibrio fischeri). (668)
Gene Name(s) luxR
Protein Name(s) Transcriptional activator protein LuxR
External Links
UniProt P12746
EMBL M25751
M19039
M25752
AF170104
Y00509
PIR B33538
S06314
ProteinModelPortal P12746
IntAct P12746
BindingDB P12746
ChEMBL CHEMBL5351
GO GO:0003677
GO:0008218
GO:0045893
GO:0009372
GO:0006351
Gene3D 1.10.10.10
3.30.450.80
InterPro IPR016032
IPR005143
IPR000792
IPR011991
Pfam PF03472
PF00196
PRINTS PR00038
SMART SM00421
SUPFAM SSF46894
SSF75516
PROSITE PS00622
PS50043

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1905087

positive regulation of bioluminescence

PMID:10913092[1]

ECO:0000315

P

Table 1 displays results of autoinducing molecules that can trigger the LuxR mutant into bioluminescing. Fig 2 signifies that when the luxR is not present the bioluminescence is significantly decreased in the colonized juvenile squids.

complete
CACAO 11360

GO:0045893

positive regulation of transcription, DNA-templated

PMID:1597420[2]

ECO:0000314

P

Fig. 1: the operator and the arrows indicate the direction of transcription from the two characterized of promoters.

complete
CACAO 11415

GO:0052043

modification by symbiont of host cellular component

PMID:10913092[1]

ECO:0000315

P

The table in Figure 5 shows the decreased levels of cytoplasm in the LuxR mutant vs the uninfected squids and wild type infected squids.

complete
CACAO 11681

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:1987152[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016032

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000792
InterPro:IPR016032

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0008218

bioluminescence

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0455

P

Seeded From UniProt

complete

involved_in

GO:0009372

quorum sensing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0673

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:1987152[3]

ECO:0000314

P

Figure 2 shows the dual requirement for both IPTG and autoinducer to increase luciferase synthesis from pGS107 (lux R mutant strain) demonstrated that LuxR was able to activate transcription of operon lux in an autoinducer-dependent fashion.

complete
CACAO 8749

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Visick, KL et al. (2000) Vibrio fischeri lux genes play an important role in colonization and development of the host light organ. J. Bacteriol. 182 4578-86 PubMed GONUTS page
  2. Choi, SH & Greenberg, EP (1992) Genetic dissection of DNA binding and luminescence gene activation by the Vibrio fischeri LuxR protein. J. Bacteriol. 174 4064-9 PubMed GONUTS page
  3. 3.0 3.1 Shadel, GS & Baldwin, TO (1991) The Vibrio fischeri LuxR protein is capable of bidirectional stimulation of transcription and both positive and negative regulation of the luxR gene. J. Bacteriol. 173 568-74 PubMed GONUTS page