ACIBY:B0V737

Species (Taxon ID)	Acinetobacter baumannii (strain AYE). (509173)
Gene Name(s)	smvA (ECO:0000313 with EMBL:CAM86420.1)
Protein Name(s)	Methyl viologen resistance protein (MFS superfamily) (ECO:0000313 with EMBL:CAM86420.1)
External Links
UniProt	B0V737
EMBL	CU459141
RefSeq	YP_001713420.1
STRING	509173.ABAYE1518
EnsemblBacteria	CAM86420
GeneID	6001273
KEGG	aby:ABAYE1518
PATRIC	20726402
eggNOG	COG0477
HOGENOM	HOG000239124
KO	K08167
OMA	IIMTSFP
OrthoDB	EOG6K6V9J
BioCyc	ABAU509173:GJXF-1478-MONOMER
Proteomes	UP000002446
GO	GO:0016021 GO:0055085
InterPro	IPR011701 IPR020846 IPR001411
Pfam	PF07690
PRINTS	PR01036
SUPFAM	SSF103473
PROSITE	PS50850

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011701	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011701	P		Seeded From UniProt	complete
	GO:0015307	drug:proton antiporter activity	PMID:20573661	ECO:0000315			F		Figure 1 shows that AmvA confers resistance in E.coli cells carrying the A.baumanii AmvA to antibiotics. Addition of the proton motive force decoupler CCCP renders the bacteria susceptible again. Figure 2 shows that A.baumanii and E.coli carrying the A.baumanii amva gene accumulate ethidium bromide and acriflavine more slowly compared to wild-type E.coli. Once CCCP is added, the concentration of these two increases sharply, implying a proton motive force driven transport of the drugs out of the cell prior to addition of the CCCP.	complete CACAO 10686
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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References

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