9CAUD:S5YPI0

Species (Taxon ID)	Bacillus phage Troll. (1382932)
Gene Name(s)	110 (ECO:0000313 with EMBL:AGT13393.1)
Protein Name(s)	DNA helicase 2 (ECO:0000313 with EMBL:AGT13393.1)
External Links
UniProt	S5YPI0
EMBL	KF208639
RefSeq	YP_008430894.1
GeneID	16575367
GO	GO:0005524 GO:0003677 GO:0004386
Gene3D	3.40.50.300
InterPro	IPR006935 IPR014001 IPR001650 IPR027417
Pfam	PF00271 PF04851
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS51192 PS51194

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004386	helicase activity	PMID:9233823	ECO:0000315			F		UvsW acts as an Helicase in T4-bacteriophage, where it functions to unwind DNA/RNA double strands and suppress the R loops in order for the replication process to take place. Table 1. results show that when a UvsW protein was inserted into a E.coli double mutant, which lacked rnhA protein and caused formation of R loops and lead to cell death, it suppressed the R loop formation.	complete CACAO 10885
Contributes to	GO:0006268	DNA unwinding involved in DNA replication	other:PMC3729639	ECO:0000314			P		Even though UvsW acts as a Helicase in T4-bacteriophage, it requires the help of another protein gp32. gp32 is a DNA-binding protein, when bounded to the unwinded DNA, enhances the conversion of D-loop structures into unwinded structures. Table1b, lanes 7-12 contains D-loop radioactively labeled dsDNA covered with 2uM of gp32 proteins and exposed to UvsW protein at different time points. Compared to the lanes 1-6, which do no contain gp32 proteins, D-loop structures were relieved at a faster rate in the presence of gp32 proteins.	complete CACAO 10895
enables	GO:0004386	helicase activity	PMID:9233823	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
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References

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