9CAUD:O56785

Species (Taxon ID)	Staphylococcus phage 187. (55511)
Gene Name(s)	ply187 (ECO:0000313 with EMBL:CAA69022.1)
Protein Name(s)	Cell wall hydrolase Ply187 (ECO:0000313 with EMBL:CAA69022.1)
External Links
UniProt	O56785
EMBL	Y07740
CAZy	GH73
GO	GO:0004040
InterPro	IPR007921 IPR013338 IPR002901
Pfam	PF05257 PF01832
SMART	SM00047
PROSITE	PS50911

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016787	hydrolase activity	PMID:10419939	ECO:0000314			F		Expression of a fragment ply187 gave only 297 aa chain which represent only 47% of the protein entire length. Individual lysis activity only different fragments of the gene were performed and showed that peptidoglycan hydrolyzing activity were highest at N termites of the protein. (Shown in figure 3)	complete CACAO 11496
	GO:0034290	holin activity	PMID:10419939	ECO:0000315			F		Figure 1B and 4 showed the present of Ply-Holin protein embedded at beginning of N terminus of this whole gene. The graphs showed the protein as hydrophobic beta turn linker, dual start motif stretch of hydrophobic amino acid. When tested this holin sequence in Ecoli, it caused well wall degradation. Mutation at at cys residue to lysine caused less damage to the cell.	complete CACAO 11497
enables	GO:0004040	amidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002901	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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