Category:GO:0140911 ! pore-forming activity

name: pore-forming activity
namespace: molecular_function
alt_id: GO:0034290
alt_id: GO:0034291
alt_id: GO:0034292
def: "An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death." [PMID:1406491, PMID:25157079, PMID:34387717]
synonym: "canonical holin activity" NARROW []
synonym: "holin activity" NARROW []
synonym: "pinholin activity" NARROW []
synonym: "pore forming activity" EXACT []
xref: TC:1.C
is_a: GO:0003674 ! molecular_function

AmiGO <GOterm>GO:0140911</GOterm>
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