YERPE:YOPM

Species (Taxon ID)	Yersinia pestis. (632)
Gene Name(s)	yopM (synonyms: yop48)
Protein Name(s)	Outer membrane protein YopM
External Links
UniProt	P17778
EMBL	AF074612 AF053946 AL117189 AE017043
PIR	A33950 T43599
RefSeq	NP_395161.1 NP_857756.1 NP_857953.1 WP_002229779.1
PDB	1G9U 1JL5
PDBsum	1G9U 1JL5
ProteinModelPortal	P17778
SMR	P17778
IntAct	P17778
DNASU	1149317
EnsemblBacteria	AAS58577
GeneID	1149317 1172671 15151810
KEGG	ype:YPCD1.26c ypm:YP_pCD60
PATRIC	fig|214092.21.peg.33
HOGENOM	HOG000219598
EvolutionaryTrace	P17778
Proteomes	UP000000815 UP000001019
GO	GO:0009279 GO:0005737 GO:0005576 GO:0046872
Gene3D	3.80.10.10
InterPro	IPR001611 IPR032675 IPR032674
Pfam	PF12468
PROSITE	PS51450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002352077 dictyBase:DDB_G0294094	C		Seeded From UniProt
part_of	GO:0009279	cell outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0998 UniProtKB-SubCell:SL-0040	C		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002352077 dictyBase:DDB_G0294094	C		Seeded From UniProt
part_of	GO:0009279	cell outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0998 UniProtKB-SubCell:SL-0040	C		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt
part_of	GO:0009279	cell outer membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0040	C		Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C		Seeded From UniProt
	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process	PMID:27911947	ECO:0000279	qualitative western immunoblotting evidence used in manual assertion		P		Figure 2D shows Western Blot data showing decreased pro-Caspase-1 and IL-1B, the inactive form of Caspase-1 that plays a role in Pyrin Inflammasome activation and the inactive form of IL-1B that is activated by Caspase-1, respectively, in the YopM mutants. This is indicative of more activation of Caspase-1 and IL-1B in the absence of YopM, which implies increased Pyrin Inflammasome activation. The figure also shows increased IL-1B in the YopM mutant, which inversely corresponds with the IL-1B protein expression data. Yersinia pests	complete CACAO 13587
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References

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