YERPE:Q93NB6

Species (Taxon ID)	Yersinia pestis. (632)
Gene Name(s)	glpD (ECO:0000313 with EMBL:AAK66002.1)
Protein Name(s)	Glycerol-3-phosphate dehydrogenase (ECO:0000256 with RuleBase:RU361217)
External Links
UniProt	Q93NB6
EMBL	AF377928
ProteinModelPortal	Q93NB6
eggNOG	ENOG4105C6V COG0578
GO	GO:0009331 GO:0052591 GO:0006072
Gene3D	3.50.50.60
InterPro	IPR006076 IPR036188 IPR000447
PANTHER	PTHR11985
Pfam	PF01266
PRINTS	PR01001
SUPFAM	SSF51905
PROSITE	PS00977

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447	F		Seeded From UniProt
involved_in	GO:0006072	glycerol-3-phosphate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447	P		Seeded From UniProt
part_of	GO:0009331	glycerol-3-phosphate dehydrogenase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447	C		Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006076	F		Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447 InterPro:IPR006076	P		Seeded From UniProt
enables	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.5.3	F		Seeded From UniProt
enables	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.5.3	F		Seeded From UniProt
enables	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.5.3	F		Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt
part_of	GO:0009331	glycerol-3-phosphate dehydrogenase complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000067708	C		Seeded From UniProt
involved_in	GO:0006072	glycerol-3-phosphate metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000067708	P		Seeded From UniProt
enables	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447	F		Seeded From UniProt
involved_in	GO:0006072	glycerol-3-phosphate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447	P		Seeded From UniProt
part_of	GO:0009331	glycerol-3-phosphate dehydrogenase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447	C		Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006076	F		Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000447 InterPro:IPR006076	P		Seeded From UniProt
enables	GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.5.3	F		Seeded From UniProt
enables	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.5.3	F		Seeded From UniProt
enables	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.5.3	F		Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt
part_of	GO:0009331	glycerol-3-phosphate dehydrogenase complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000067708	C		Seeded From UniProt
involved_in	GO:0006072	glycerol-3-phosphate metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000067708	P		Seeded From UniProt
	GO:0019662	non-glycolytic fermentation	PMID:25220241	ECO:0006049	genetic transformation evidence used in manual assertion		P		Table 2: Two different strains of Y. pestis, KIM6+, with a functional glpD gene, and CO92L, with a 93 bp inframe deletion of the glpD allele, were tested for glycerol fermentation under differing conditions. Glycerol fermentation was visualized by indicator plates. Unmodified strains were utilized as controls, in which KIM6+ was positive for glycerol fermentation and CO92L was negative for glycerol fermentation. Allelic exchange was used to exchange the functional glpD in KIM6+ with the nonfunctional glpD of CO92L. The nonfunctional glpD of CO92L was exchanged with the functional glpD of KIM6+. KIM6+ with nonfunctional glpD and CO92L with the functional glpD showed no indicators of glycerol fermentation. Glycerol fermentation was restored in the mutant KIM6+ with nonfunctional glpD when a plasmid vector of functional glpD derived from KIM6+ was added. This is evidence lack of glpD can disrupt glycerol fermentation. GO Term non-glycolytic fermentation was chosen due to the function of glpD. glpD in this experiment participates in aerobic glycerol fermentation to help form pyruvate from glycerol which does not involve the use of glycolysis as in glycolysis fermentation.	complete CACAO 13554
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