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YEAST:UBP6
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | UBP6 | |
| Protein Name(s) | Ubiquitin carboxyl-terminal hydrolase 6
Deubiquitinating enzyme 6 Ubiquitin thioesterase 6 Ubiquitin-specific-processing protease 6 | |
| External Links | ||
| UniProt | P43593 | |
| EMBL | D50617 BK006940 | |
| PIR | S56265 | |
| RefSeq | NP_116665.1 | |
| PDB | 1VJV | |
| PDBsum | 1VJV | |
| ProteinModelPortal | P43593 | |
| SMR | P43593 | |
| BioGrid | 31160 | |
| DIP | DIP-6731N | |
| IntAct | P43593 | |
| MINT | MINT-619095 | |
| STRING | 4932.YFR010W | |
| MEROPS | C19.079 | |
| MoonProt | P43593 | |
| MaxQB | P43593 | |
| PaxDb | P43593 | |
| PeptideAtlas | P43593 | |
| EnsemblFungi | [example_ID YFR010W] | |
| GeneID | 850562 | |
| KEGG | sce:YFR010W | |
| CYGD | YFR010w | |
| SGD | S000001906 | |
| eggNOG | NOG286607 | |
| GeneTree | ENSGT00390000009615 | |
| HOGENOM | HOG000202292 | |
| InParanoid | P43593 | |
| KO | K11843 | |
| OMA | ELCTTEL | |
| OrthoDB | EOG789CMF | |
| BioCyc | YEAST:G3O-30463-MONOMER | |
| EvolutionaryTrace | P43593 | |
| NextBio | 966361 | |
| PRO | PR:P43593 | |
| Proteomes | UP000002311 | |
| Genevestigator | P43593 | |
| GO | GO:0000502 GO:0005838 GO:0004843 GO:1901799 GO:0016579 GO:0006511 | |
| InterPro | IPR001394 IPR000626 IPR029071 IPR018200 IPR028889 | |
| Pfam | PF00443 | |
| SMART | SM00213 | |
| SUPFAM | SSF54236 | |
| PROSITE | PS00972 PS00973 PS50235 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032434 |
regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000315 |
P |
Figure 5(A) The immunoblot analysis indicates that the blot of Ubp6 mutant accumulates ubiquitylated proteins unlike the wild type cells. Figure 4 (D) Double deletion of Ubp6 and hsm3 shows the most noticeable growth defect due to lack of proteasomal assembly. |
complete | |||||
|
involved_in |
GO:0072671 |
mitochondria-associated ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P07213)|has_input:(UniProtKB:P53083)|has_input:(UniProtKB:P28737) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032434 |
regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901799 |
negative regulation of proteasomal protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016579 |
protein deubiquitination |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001900 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016579 |
protein deubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005838 |
proteasome regulatory particle |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000502 |
proteasome complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016579 |
protein deubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036459 |
thiol-dependent ubiquitinyl hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036459 |
thiol-dependent ubiquitinyl hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sakata, E et al. (2011) The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle. Mol. Cell 42 637-49 PubMed GONUTS page
- ↑ Heo, JM et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol. Cell 40 465-80 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Hanna, J et al. (2006) Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell 127 99-111 PubMed GONUTS page
- ↑ Guterman, A & Glickman, MH (2004) Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome. J. Biol. Chem. 279 1729-38 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Leggett, DS et al. (2002) Multiple associated proteins regulate proteasome structure and function. Mol. Cell 10 495-507 PubMed GONUTS page
- ↑ Verma, R et al. (2000) Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol. Biol. Cell 11 3425-39 PubMed GONUTS page
