YEAST:MDV1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	MDV1 (synonyms: FIS2, GAG3, NET2)
Protein Name(s)	Mitochondrial division protein 1 Mitochondria fission 2 protein
External Links
UniProt	P47025
EMBL	Z49387 BK006943
PIR	S56893
RefSeq	NP_012423.1
PDB	2PQN 2XU6 3UUX
PDBsum	2PQN 2XU6 3UUX
ProteinModelPortal	P47025
SMR	P47025
BioGrid	33644
DIP	DIP-1907N
IntAct	P47025
MINT	MINT-389558
STRING	4932.YJL112W
MaxQB	P47025
PaxDb	P47025
EnsemblFungi	[example_ID YJL112W]
GeneID	853332
KEGG	sce:YJL112W
CYGD	YJL112w
SGD	S000003648
eggNOG	COG2319
GeneTree	ENSGT00770000120636
HOGENOM	HOG000048466
InParanoid	P47025
KO	K17970
OMA	NDRESAF
OrthoDB	EOG7X0VRS
BioCyc	YEAST:G3O-31566-MONOMER
EvolutionaryTrace	P47025
NextBio	973700
Proteomes	UP000002311
Genevestigator	P47025
GO	GO:0005741 GO:0043130 GO:0000266 GO:0000002 GO:0016559 GO:0090141
Gene3D	2.130.10.10
InterPro	IPR020472 IPR021061 IPR015943 IPR001680 IPR019775 IPR017986
Pfam	PF11542 PF00400
PRINTS	PR00320
SMART	SM00320
SUPFAM	SSF50978
PROSITE	PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0000266	mitochondrial fission	PMID:22575664^[1]	ECO:0000314			P	Seeded from Uniprot	complete CACAO 7998
part_of	GO:0005739	mitochondrion	PMID:16823961^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:16407407^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:24769239^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:21070969^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0016559	peroxisome fission	PMID:18445678^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001709 SGD:S000001744	P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:11038182^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:11038180^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:11179417^[9]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000003924	P	Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:11038182^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54861	P	Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:11179417^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000383	P	Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:11038180^[8]	ECO:0000316	genetic interaction evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0000266	mitochondrial fission	PMID:11038183^[10]	ECO:0000316	genetic interaction evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0000266	mitochondrial fission	PMID:11038182^[7]	ECO:0000316	genetic interaction evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0000266	mitochondrial fission	PMID:11179417^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:11038183^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:11038180^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:11038182^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000002	mitochondrial genome maintenance	PMID:11038182^[7]	ECO:0000316	genetic interaction evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0000002	mitochondrial genome maintenance	PMID:11038182^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	PMID:23530241^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458182 SGD:S000001451	F	Seeded From UniProt	complete
involved_in	GO:0042273	ribosomal large subunit biogenesis	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000458182 SGD:S000001451	P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bradshaw, E et al. (2012) Mitochondrial fission proteins Fis1 and Mdv1, but not Dnm1, play a role in maintenance of heteroplasmy in budding yeast. FEBS Lett. 586 1245-51 PubMed GONUTS page
↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
↑ Zahedi, RP et al. (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol. Biol. Cell 17 1436-50 PubMed GONUTS page
↑ Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page
↑ Pashkova, N et al. (2010) WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol. Cell 40 433-43 PubMed GONUTS page
↑ Motley, AM et al. (2008) Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p. J. Cell. Sci. 121 1633-40 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Tieu, Q & Nunnari, J (2000) Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J. Cell Biol. 151 353-66 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Fekkes, P et al. (2000) Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J. Cell Biol. 151 333-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Cerveny, KL et al. (2001) Division of mitochondria requires a novel DMN1-interacting protein, Net2p. Mol. Biol. Cell 12 309-21 PubMed GONUTS page
↑ ^10.0 ^10.1 Mozdy, AD et al. (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151 367-80 PubMed GONUTS page
↑ Koirala, S et al. (2013) Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc. Natl. Acad. Sci. U.S.A. 110 E1342-51 PubMed GONUTS page
↑ ^12.0 ^12.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22575664-1] Bradshaw, E et al. (2012) Mitochondrial fission proteins Fis1 and Mdv1, but not Dnm1, play a role in maintenance of heteroplasmy in budding yeast. FEBS Lett. 586 1245-51 PubMed GONUTS page

[PMID:16823961-2] Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page

[PMID:16407407-3] Zahedi, RP et al. (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol. Biol. Cell 17 1436-50 PubMed GONUTS page

[PMID:24769239-4] Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page

[PMID:21070969-5] Pashkova, N et al. (2010) WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol. Cell 40 433-43 PubMed GONUTS page

[PMID:18445678-6] Motley, AM et al. (2008) Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p. J. Cell. Sci. 121 1633-40 PubMed GONUTS page

[PMID:11038182-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Tieu, Q & Nunnari, J (2000) Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J. Cell Biol. 151 353-66 PubMed GONUTS page

[PMID:11038180-8] 8.0 ^8.1 ^8.2 Fekkes, P et al. (2000) Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J. Cell Biol. 151 333-40 PubMed GONUTS page

[PMID:11179417-9] 9.0 ^9.1 ^9.2 Cerveny, KL et al. (2001) Division of mitochondria requires a novel DMN1-interacting protein, Net2p. Mol. Biol. Cell 12 309-21 PubMed GONUTS page

[PMID:11038183-10] 10.0 ^10.1 Mozdy, AD et al. (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151 367-80 PubMed GONUTS page

[PMID:23530241-11] Koirala, S et al. (2013) Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc. Natl. Acad. Sci. U.S.A. 110 E1342-51 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:MDV1

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