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YEAST:KOG1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) KOG1 (synonyms: LAS24)
Protein Name(s) Target of rapamycin complex 1 subunit KOG1

TORC1 subunit KOG1 Kontroller of growth protein 1 Local anesthetic-sensitive protein 24

External Links
UniProt P38873
EMBL U00030
BK006934
PIR S46686
RefSeq NP_012056.1
ProteinModelPortal P38873
BioGrid 36620
DIP DIP-2639N
IntAct P38873
MINT MINT-426011
STRING 4932.YHR186C
iPTMnet P38873
MaxQB P38873
PRIDE P38873
EnsemblFungi YHR186C
GeneID 856593
KEGG sce:YHR186C
EuPathDB FungiDB:YHR186C
SGD S000001229
GeneTree ENSGT00640000091541
HOGENOM HOG000184479
InParanoid P38873
KO K07204
OMA PIEMALW
OrthoDB EOG092C09V4
BioCyc YEAST:G3O-31216-MONOMER
Reactome [www.reactome.org/content/detail/R-SCE-3371571 R-SCE-3371571]
PRO PR:P38873
Proteomes UP000002311
GO GO:0010494
GO:0000329
GO:0005886
GO:0031931
GO:0030674
GO:0043130
GO:0071230
GO:0009267
GO:0030307
GO:0071902
GO:0010506
GO:0001558
GO:0008361
GO:0031929
Gene3D 1.25.10.10
2.130.10.10
InterPro IPR011989
IPR016024
IPR000357
IPR004083
IPR029347
IPR015943
IPR001680
IPR019775
IPR017986
PANTHER PTHR12848
Pfam PF02985
PF14538
SMART SM01302
SM00320
SUPFAM SSF48371
SSF50978
PROSITE PS00678
PS50082
PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005739

mitochondrion

PMID:16823961[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:26928762[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:14562095[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14576278[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0010494

cytoplasmic stress granule

PMID:26777405[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0043130

ubiquitin binding

PMID:21070969[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031931

TORC1 complex

PMID:12408816[7]

ECO:0000353

physical interaction evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:12408816[7]

ECO:0000305

curator inference used in manual assertion

GO:0031931

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:12408816[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:16394584[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001558

regulation of cell growth

PMID:12408816[7]

ECO:0000353

physical interaction evidence used in manual assertion

SGD:S000001686
SGD:S000003827

P

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:17560372[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:16394584[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071902

positive regulation of protein serine/threonine kinase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
UniProtKB:Q8N122

P

Seeded From UniProt

complete

involved_in

GO:0071230

cellular response to amino acid stimulus

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
UniProtKB:Q8N122

P

Seeded From UniProt

complete

part_of

GO:0031931

TORC1 complex

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029840
PANTHER:PTN000304084
PomBase:SPAC57A7.11
UniProtKB:Q8N122
WB:WBGene00000911

C

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
UniProtKB:Q8N122

P

Seeded From UniProt

complete

enables

GO:0030674

protein binding, bridging

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
UniProtKB:Q8N122

F

Seeded From UniProt

complete

involved_in

GO:0030307

positive regulation of cell growth

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
UniProtKB:Q8N122

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
SGD:S000001229

P

Seeded From UniProt

complete

involved_in

GO:0008361

regulation of cell size

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
UniProtKB:Q8N122

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304084
PomBase:SPAC57A7.11
UniProtKB:Q8N122

C

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004083

P

Seeded From UniProt

complete

part_of

GO:0031931

TORC1 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004083

C

Seeded From UniProt

complete

part_of

GO:0005773

vacuole

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0926

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  2. ↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
  3. ↑ Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
  4. ↑ Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
  5. ↑ Jain, S et al. (2016) ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 164 487-98 PubMed GONUTS page
  6. ↑ Pashkova, N et al. (2010) WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol. Cell 40 433-43 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Loewith, R et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10 457-68 PubMed GONUTS page
  8. ↑ 8.0 8.1 Araki, T et al. (2005) LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Genes Genet. Syst. 80 325-43 PubMed GONUTS page
  9. ↑ Urban, J et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol. Cell 26 663-74 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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