YEAST:KAD1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	ADK1 (synonyms: AKY, AKY1, AKY2)
Protein Name(s)	Adenylate kinase 1 AK 1 ATP-AMP transphosphorylase 1 Adenylate kinase cytosolic and mitochondrial
External Links
UniProt	P07170
EMBL	X06304 Y00413 M18455 U13239 Z48612 AY558578 BK006938
PIR	S05799
RefSeq	NP_010512.1
PDB	1AKY 1DVR 2AKY 3AKY
PDBsum	1AKY 1DVR 2AKY 3AKY
ProteinModelPortal	P07170
SMR	P07170
DIP	DIP-5129N
IntAct	P07170
MINT	MINT-501634
STRING	4932.YDR226W
SWISS-2DPAGE	P07170
PaxDb	P07170
PeptideAtlas	P07170
PRIDE	P07170
EnsemblFungi	[example_ID YDR226W]
GeneID	851812
KEGG	sce:YDR226W
CYGD	YDR226w
SGD	S000002634
eggNOG	COG0563
GeneTree	ENSGT00700000104498
HOGENOM	HOG000238772
KO	K00939
OMA	QADAMKD
OrthoDB	EOG4X0R28
EvolutionaryTrace	P07170
NextBio	969668
Genevestigator	P07170
GermOnline	YDR226W
GO	GO:0005829 GO:0005758 GO:0004017 GO:0005524 GO:0006172 GO:0006270
InterPro	IPR006259 IPR000850 IPR007862
PANTHER	PTHR23359
Pfam	PF00406 PF05191
PRINTS	PR00094
SUPFAM	SSF57774
TIGRFAMs	TIGR01351
PROSITE	PS00113

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005739	mitochondrion	PMID:16823961^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:24769239^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009117	nucleotide metabolic process	PMID:2850178^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006270	DNA replication initiation	PMID:20980819^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006172	ADP biosynthetic process	PMID:2848829^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:2850178^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:2850178^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	PMID:18433446^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	PMID:2850178^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	PMID:18433446^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	PMID:15753074^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
involved_in	GO:0046940	nucleoside monophosphate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004017	P	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006259 InterPro:IPR007862 InterPro:IPR028587	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000850 InterPro:IPR006259	F	Seeded From UniProt	complete
involved_in	GO:0006139	nucleobase-containing compound metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000850	P	Seeded From UniProt	complete
involved_in	GO:0006172	ADP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028587	P	Seeded From UniProt	complete
enables	GO:0016776	phosphotransferase activity, phosphate group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006259	F	Seeded From UniProt	complete
enables	GO:0019205	nucleobase-containing compound kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000850	F	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.4.3	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165914	C	Seeded From UniProt	complete
involved_in	GO:0046033	AMP metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165914	P	Seeded From UniProt	complete
involved_in	GO:0046034	ATP metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165914	P	Seeded From UniProt	complete
enables	GO:0004017	adenylate kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165914	F	Seeded From UniProt	complete
involved_in	GO:0006172	ADP biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165914	P	Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165914	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0169	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
↑ Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Bandlow, W et al. (1988) Yeast adenylate kinase is active simultaneously in mitochondria and cytoplasm and is required for non-fermentative growth. Eur. J. Biochem. 178 451-7 PubMed GONUTS page
↑ Ma, L et al. (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9 4399-410 PubMed GONUTS page
↑ Konrad, M (1988) Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 263 19468-74 PubMed GONUTS page
↑ ^6.0 ^6.1 Gauthier, S et al. (2008) Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations. Mol. Microbiol. 68 1583-94 PubMed GONUTS page
↑ Gu, Y et al. (2005) A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity. J. Biol. Chem. 280 18604-9 PubMed GONUTS page

[PMID:16823961-1] Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page

[PMID:24769239-2] Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page

[PMID:2850178-3] 3.0 ^3.1 ^3.2 ^3.3 Bandlow, W et al. (1988) Yeast adenylate kinase is active simultaneously in mitochondria and cytoplasm and is required for non-fermentative growth. Eur. J. Biochem. 178 451-7 PubMed GONUTS page

[PMID:20980819-4] Ma, L et al. (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9 4399-410 PubMed GONUTS page

[PMID:2848829-5] Konrad, M (1988) Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 263 19468-74 PubMed GONUTS page

[PMID:18433446-6] 6.0 ^6.1 Gauthier, S et al. (2008) Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations. Mol. Microbiol. 68 1583-94 PubMed GONUTS page

[PMID:15753074-7] Gu, Y et al. (2005) A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity. J. Biol. Chem. 280 18604-9 PubMed GONUTS page

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YEAST:KAD1

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