YEAST:FDC1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	No Information Provided.
Protein Name(s)	Ferulic acid decarboxylase 1 (ECO:0000255 with HAMAP-Rule:MF_03196, ECO:0000303 with PMID:20471595^[1]) Phenacrylate decarboxylase (ECO:0000255 with HAMAP-Rule:MF_03196)
External Links
UniProt	Q03034
EMBL	U43834 BK006938
PIR	S62018
RefSeq	NP_010828.1
PDB	4S13 4ZAC 6EVE 6EVF
PDBsum	4S13 4ZAC 6EVE 6EVF
ProteinModelPortal	Q03034
SMR	Q03034
BioGrid	32586
DIP	DIP-7852N
IntAct	Q03034
STRING	4932.YDR539W
MaxQB	Q03034
PaxDb	Q03034
PRIDE	Q03034
EnsemblFungi	YDR539W_mRNA
GeneID	852152
KEGG	sce:YDR539W
EuPathDB	FungiDB:YDR539W
SGD	S000002947
GeneTree	ENSGT00940000176404
InParanoid	Q03034
KO	K20039
OMA	VLTEGGC
BioCyc	MetaCyc:G3O-30047-MONOMER YEAST:G3O-30047-MONOMER
PRO	PR:Q03034
Proteomes	UP000002311
GO	GO:0005737 GO:0016831 GO:0046872 GO:0046281 GO:0033494
HAMAP	MF_01983
InterPro	IPR002830 IPR032903
PANTHER	PTHR30108
Pfam	PF01977
TIGRFAMs	TIGR00148

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:14562095^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25647642^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:27386)	Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25647642^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:17620)	Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25647642^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:23401)	Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	PMID:25862228^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	PMID:25862228^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25862228^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(CHEBI:17620) has_direct_input:(CHEBI:36090)	Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25862228^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:17620) has_direct_input:(CHEBI:36090)	Seeded From UniProt
involved_in	GO:0046281	cinnamic acid catabolic process	PMID:20471595^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0046281	cinnamic acid catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000764650 SGD:S000002947	P		Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000764650 SGD:S000002947	P		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000764648 SGD:S000002947	F		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002830	F		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	C		Seeded From UniProt
involved_in	GO:0046281	cinnamic acid catabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	P		Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	P		Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0210	F		Seeded From UniProt
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt
part_of	GO:0005737	cytoplasm	PMID:14562095^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25647642^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:27386)	Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25647642^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:17620)	Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25647642^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:23401)	Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	PMID:25862228^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	PMID:25862228^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25862228^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(CHEBI:17620) has_direct_input:(CHEBI:36090)	Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:25862228^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:17620) has_direct_input:(CHEBI:36090)	Seeded From UniProt
involved_in	GO:0046281	cinnamic acid catabolic process	PMID:20471595^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt
involved_in	GO:0046281	cinnamic acid catabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000764650 SGD:S000002947	P		Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000764650 SGD:S000002947	P		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000764648 SGD:S000002947	F		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002830	F		Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0210	F		Seeded From UniProt
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0086	C		Seeded From UniProt
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	F		Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	C		Seeded From UniProt
involved_in	GO:0046281	cinnamic acid catabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	P		Seeded From UniProt
involved_in	GO:0033494	ferulate metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000200341	P		Seeded From UniProt
	GO:1901067	ferulate catabolic process	PMID:30625138^[6]	ECO:0001258	spectrophotometry evidence used in manual assertion		P		Figures 2 and 3 shows that Fdc1 (Ferulic acid decarboxylase 1) positively regulates the decarboxylation of ferulic acid in S. cerevisiae.	complete CACAO 13747
	GO:0006113	fermentation	PMID:30625138^[6]	ECO:0007680			P		Figure 4C shows that Fdc1 (Ferulic acid decarboxylase 1) positively regulates the production of 4VG in S. cerevisiae.	complete
	GO:1901468	positive regulation of ferulate catabolic process	PMID:30625138^[6]	ECO:0001258			P		Figures 2 and 3 shows that Fdc1 (Ferulic acid decarboxylase 1) positively regulates the decarboxylation of ferulic acid in S. eubayanus.	complete
	GO:0006113	fermentation	PMID:30625138^[6]	ECO:0007680			P		Figure 4C shows that Fdc1 (Ferulic acid decarboxylase 1) positively regulates the production of 4VG in S. eubayanus.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Mukai, N et al. (2010) PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae. J. Biosci. Bioeng. 109 564-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lin, F et al. (2015) Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase. ACS Chem. Biol. 10 1137-44 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Bhuiya, MW et al. (2015) Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae. Appl. Environ. Microbiol. 81 4216-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Mertens, S et al. (2019) Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts. PLoS ONE 14 e0209124 PubMed GONUTS page

[PMID:20471595-1] 1.0 ^1.1 ^1.2 Mukai, N et al. (2010) PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae. J. Biosci. Bioeng. 109 564-9 PubMed GONUTS page

[PMID:14562095-2] 2.0 ^2.1 Huh, WK et al. (2003) Global analysis of protein localization in budding yeast. Nature 425 686-91 PubMed GONUTS page

[PMID:25647642-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lin, F et al. (2015) Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase. ACS Chem. Biol. 10 1137-44 PubMed GONUTS page

[PMID:25862228-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Bhuiya, MW et al. (2015) Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae. Appl. Environ. Microbiol. 81 4216-23 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:30625138-6] 6.0 ^6.1 ^6.2 ^6.3 Mertens, S et al. (2019) Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts. PLoS ONE 14 e0209124 PubMed GONUTS page

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YEAST:FDC1

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