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YEAST:CCW12
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | CCW12 | |
| Protein Name(s) | Covalently-linked cell wall protein 12
Protein Alpha0.6 | |
| External Links | ||
| UniProt | Q12127 | |
| EMBL | Z73282 U53878 AY557929 BK006945 | |
| PIR | S64947 | |
| RefSeq | NP_013211.1 | |
| ProteinModelPortal | Q12127 | |
| BioGrid | 31383 | |
| DIP | DIP-4570N | |
| IntAct | Q12127 | |
| MINT | MINT-553030 | |
| STRING | 4932.YLR110C | |
| MaxQB | Q12127 | |
| PaxDb | Q12127 | |
| EnsemblFungi | [example_ID YLR110C] | |
| GeneID | 850800 | |
| KEGG | sce:YLR110C | |
| CYGD | YLR110c | |
| SGD | S000004100 | |
| eggNOG | NOG39341 | |
| GeneTree | ENSGT00660000095872 | |
| HOGENOM | HOG000001118 | |
| InParanoid | Q12127 | |
| OMA | ATYANST | |
| OrthoDB | EOG7NSBC6 | |
| BioCyc | YEAST:G3O-32257-MONOMER | |
| NextBio | 967023 | |
| Proteomes | UP000002311 | |
| Genevestigator | Q12127 | |
| GO | GO:0031225 GO:0005934 GO:0005576 GO:0009277 GO:0043332 GO:0000752 GO:0000747 GO:0031505 | |
| InterPro | IPR025928 | |
| Pfam | PF13928 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044426 |
cell wall part |
ECO:0000315 |
C |
Figure 2: yeast mutants for ccw12 protein did not have as great of an observation density compared to ccw12 wild type yeast. This demonstrates that ccw12 is integral for cell wall stability and Yeast growth. |
complete | |||||
| GO:0005199 |
structural constituent of cell wall |
ECO:0000315 |
F |
Figure 5A demonstrates that cells without the ccw12 protein underwent lysis when introduced to hypotonic shock conditions at a rate of 41%. Wild type cells which produced ccw12 protein only experienced lysis and cell death at a rate of 8% when moving from an osmotically stable environment to that of a hypotonic environment. This figure shows that without ccw12 protein present, cell lysis in daughter yeast cells occurs much more frequently during bud formation. Due to the low rate of cell death in the wild type, it can be inferred that the ccw12 protein plays a major role in stabilizing the cell wall and protecting against lysis. |
complete | |||||
|
part_of |
GO:0071944 |
cell periphery |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000324 |
fungal-type vacuole |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005199 |
structural constituent of cell wall |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043332 |
mating projection tip |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031505 |
fungal-type cell wall organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031505 |
fungal-type cell wall organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031505 |
fungal-type cell wall organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009277 |
fungal-type cell wall |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005934 |
cellular bud tip |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000752 |
agglutination involved in conjugation with cellular fusion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000747 |
conjugation with cellular fusion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000747 |
conjugation with cellular fusion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031225 |
anchored component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071555 |
cell wall organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ragni, E et al. (2007) Characterization of Ccw12p, a major key player in cell wall stability of Saccharomyces cerevisiae. Yeast 24 309-19 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Ragni, E et al. (2011) The genetic interaction network of CCW12, a Saccharomyces cerevisiae gene required for cell wall integrity during budding and formation of mating projections. BMC Genomics 12 107 PubMed GONUTS page
- ↑ 3.0 3.1 Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
- ↑ Kurischko, C et al. (2005) A role for the Saccharomyces cerevisiae regulation of Ace2 and polarized morphogenesis signaling network in cell integrity. Genetics 171 443-55 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Mrsa, V et al. (1999) Deletion of new covalently linked cell wall glycoproteins alters the electrophoretic mobility of phosphorylated wall components of Saccharomyces cerevisiae. J. Bacteriol. 181 3076-86 PubMed GONUTS page
- ↑ Hamada, K et al. (1999) Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins. J. Bacteriol. 181 3886-9 PubMed GONUTS page
