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YEAST:ATG12
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | ATG12 (synonyms: APG12) | |
| Protein Name(s) | Ubiquitin-like protein ATG12
Autophagy-related protein 12 | |
| External Links | ||
| UniProt | P38316 | |
| EMBL | AB017924 Z36086 AY557706 BK006936 | |
| PIR | S46093 | |
| RefSeq | NP_009776.1 | |
| PDB | 3W1S | |
| PDBsum | 3W1S | |
| ProteinModelPortal | P38316 | |
| SMR | P38316 | |
| BioGrid | 32914 | |
| DIP | DIP-1189N | |
| IntAct | P38316 | |
| MINT | MINT-388309 | |
| EnsemblFungi | YBR217W | |
| GeneID | 852518 | |
| KEGG | sce:YBR217W | |
| EuPathDB | FungiDB:YBR217W | |
| SGD | S000000421 | |
| HOGENOM | HOG000234863 | |
| InParanoid | P38316 | |
| KO | K08336 | |
| OMA | CYINNSF | |
| OrthoDB | EOG092C5K82 | |
| BioCyc | YEAST:G3O-29154-MONOMER | |
| PRO | PR:P38316 | |
| Proteomes | UP000002311 | |
| GO | GO:0034274 GO:0000407 GO:0034045 GO:0008047 GO:0031386 GO:0000045 GO:0006501 GO:0032258 GO:0044805 GO:0000422 GO:0034727 | |
| CDD | cd01612 | |
| InterPro | IPR007242 IPR029071 | |
| PANTHER | PTHR13385 | |
| Pfam | PF04110 | |
| SUPFAM | SSF54236 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061739 |
protein lipidation involved in autophagosome assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008047 |
enzyme activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044805 |
late nucleophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034727 |
piecemeal microautophagy of the nucleus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034274 |
Atg12-Atg5-Atg16 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032258 |
protein localization by the Cvt pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031386 |
protein tag |
ECO:0000353 |
physical interaction evidence used in manual assertion |
SGD:S000001214 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031386 |
protein tag |
ECO:0000353 |
physical interaction evidence used in manual assertion |
SGD:S000003965 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031386 |
protein tag |
ECO:0000353 |
physical interaction evidence used in manual assertion |
SGD:S000006070 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0019776 |
Atg8 ligase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:16038) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006501 |
C-terminal protein lipidation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000422 |
autophagy of mitochondrion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000407 |
phagophore assembly site |
ECO:0000305 |
curator inference used in manual assertion |
GO:0034274 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000045 |
autophagosome assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034274 |
Atg12-Atg5-Atg16 complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000333039 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034045 |
phagophore assembly site membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914776 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019776 |
Atg8 ligase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000333039 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006501 |
C-terminal protein lipidation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000333039 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000422 |
autophagy of mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000333039 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000045 |
autophagosome assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1914776 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043085 |
positive regulation of catalytic activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000045 |
autophagosome assembly |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034045 |
phagophore assembly site membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
- ↑ Kaufmann, A et al. (2014) Molecular mechanism of autophagic membrane-scaffold assembly and disassembly. Cell 156 469-81 PubMed GONUTS page
- ↑ Sakoh-Nakatogawa, M et al. (2013) Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site. Nat. Struct. Mol. Biol. 20 433-9 PubMed GONUTS page
- ↑ Mijaljica, D et al. (2012) A late form of nucleophagy in Saccharomyces cerevisiae. PLoS ONE 7 e40013 PubMed GONUTS page
- ↑ Krick, R et al. (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol. Biol. Cell 19 4492-505 PubMed GONUTS page
- ↑ 6.0 6.1 Kuma, A et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 277 18619-25 PubMed GONUTS page
- ↑ 7.0 7.1 Mizushima, N et al. (1998) A protein conjugation system essential for autophagy. Nature 395 395-8 PubMed GONUTS page
- ↑ Tanida, I et al. (1999) Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol. Biol. Cell 10 1367-79 PubMed GONUTS page
- ↑ Shintani, T et al. (1999) Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J. 18 5234-41 PubMed GONUTS page
- ↑ 10.0 10.1 Hanada, T et al. (2007) The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J. Biol. Chem. 282 37298-302 PubMed GONUTS page
- ↑ Kanki, T et al. (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol. Biol. Cell 20 4730-8 PubMed GONUTS page
- ↑ Hanada, T & Ohsumi, Y (2005) Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy. Autophagy 1 110-8 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
d
f
p
- GO:0000407 ! phagophore assembly site
- GO:0034045 ! phagophore assembly site membrane
- GO:0034727 ! piecemeal microautophagy of the nucleus
- GO:0043085 ! positive regulation of catalytic activity
- GO:0061739 ! protein lipidation involved in autophagosome assembly
- GO:0031386 ! protein tag activity
- GO:0015031 ! protein transport
