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YEAST:ALG2
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | ALG2 | |
| Protein Name(s) | Alpha-1,3/1,6-mannosyltransferase ALG2
Asparagine-linked glycosylation protein 2 GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase | |
| External Links | ||
| UniProt | P43636 | |
| EMBL | X87947 Z72587 BK006941 | |
| PIR | S64069 | |
| RefSeq | NP_011450.1 | |
| ProteinModelPortal | P43636 | |
| SMR | P43636 | |
| BioGrid | 33182 | |
| DIP | DIP-5401N | |
| IntAct | P43636 | |
| MINT | MINT-523155 | |
| STRING | 4932.YGL065C | |
| CAZy | GT4 | |
| MaxQB | P43636 | |
| PaxDb | P43636 | |
| PeptideAtlas | P43636 | |
| EnsemblFungi | [example_ID YGL065C] | |
| GeneID | 852815 | |
| KEGG | sce:YGL065C | |
| CYGD | YGL065c | |
| SGD | S000003033 | |
| eggNOG | COG0438 | |
| GeneTree | ENSGT00550000075033 | |
| HOGENOM | HOG000177048 | |
| InParanoid | P43636 | |
| KO | K03843 | |
| OMA | GETGWLR | |
| OrthoDB | EOG7G4QQG | |
| BioCyc | MetaCyc:MONOMER-7186 YEAST:YGL065C-MONOMER | |
| Reactome | REACT_250523 | |
| UniPathway | UPA00378 | |
| NextBio | 972351 | |
| PRO | PR:P43636 | |
| Proteomes | UP000002311 | |
| Genevestigator | P43636 | |
| GO | GO:0005783 GO:0005789 GO:0016021 GO:0004378 GO:0033164 GO:0097502 GO:0006490 GO:0006486 | |
| InterPro | IPR027054 IPR001296 IPR028098 | |
| PANTHER | PTHR12526:SF221 | |
| Pfam | PF13439 PF00534 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044093 |
positive regulation of molecular function |
ECO:0000314 |
P |
Ca2+ inhibited budding starting at concentrations greater than 1.2 mM, whereas addition of recombinant ALG-2 inhibited budding at a lower concentration of 300 uM Ca2+. Figure 1 |
complete | |||||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033164 |
glycolipid 6-alpha-mannosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006490 |
oligosaccharide-lipid intermediate biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000305 |
curator inference used in manual assertion |
GO:0006490 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004378 |
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033577 |
protein glycosylation in endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000282458 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006490 |
oligosaccharide-lipid intermediate biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000282458 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000033 |
alpha-1,3-mannosyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000282458 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097502 |
mannosylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004378 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097502 |
mannosylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0000009 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097502 |
mannosylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004378 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097502 |
mannosylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0033164 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097502 |
mannosylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0000033 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097502 |
mannosylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004378 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004378 |
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004378 |
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102704 |
GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-SCE-449748 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000009 |
alpha-1,6-mannosyltransferase activity |
Reactome:R-SCE-449748 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ la Cour, JM et al. (2013) ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex. PLoS ONE 8 e75309 PubMed GONUTS page
- ↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 O'Reilly, MK et al. (2006) In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. Biochemistry 45 9593-603 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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