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XENLA:Q8UVQ6
Contents
| Species (Taxon ID) | Xenopus laevis (African clawed frog). (8355) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Neuralized (ECO:0000313 with EMBL:AAL69890.1) | |
| External Links | ||
| UniProt | Q8UVQ6 | |
| EMBL | AF419159 | |
| UniGene | Xl.17387 | |
| ProteinModelPortal | Q8UVQ6 | |
| HOVERGEN | HBG052606 | |
| GO | GO:0008270 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR006573 IPR001841 IPR013083 | |
| Pfam | PF07177 | |
| SMART | SM00588 SM00184 | |
| PROSITE | PS51065 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0007219 |
Notch signaling pathway |
ECO:0000315 |
P |
Figure 2. Xneur is expressed in developing neurons and skin cells whose fate is determined by the Notch pathway. Injection of RNA that upregulates Notch resulted in reduced Xneur expression. Conversely, injection with an RNA that inactivated Notch resulted in increased Xneur expression. This implicates Xenopus neuralized in the Notch signaling pathway. |
complete | |||||
| GO:0004842 |
ubiquitin-protein ligase activity |
ECO:0000314 |
F |
Figure 5. A direct biochemical assay was carried out in which the RF domain from Xneur was incubated with an E1, E2, and ATP. Immunostaining with anti-ubiquitin antibodies revealed high molecular weight smears of ubiquitin staining, consistent with self-ubiquitination of Xneur. |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Deblandre, GA et al. (2001) Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling. Dev. Cell 1 795-806 PubMed GONUTS page
