XENLA:Q63ZQ7

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	fbxl19 (ECO:0000313 with Xenbase:XB-GENE-994856)
Protein Name(s)	Uncharacterized protein (ECO:0000313 with EMBL:AAH82853.1)
External Links
UniProt	Q63ZQ7
EMBL	BC082853
RefSeq	NP_001167463.1
UniGene	Xl.51872
ProteinModelPortal	Q63ZQ7
GeneID	443628
KEGG	xla:443628
CTD	54620
Xenbase	XB-GENE-994856
HOVERGEN	HBG061227
KO	K10285
GO	GO:0008270
Gene3D	3.30.40.10
InterPro	IPR001810 IPR001611 IPR019786 IPR011011 IPR001965 IPR019787 IPR013083
Pfam	PF00646 PF00560
SMART	SM00249
SUPFAM	SSF57903
PROSITE	PS01359 PS50016

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	PMID:23324393	ECO:0000314			P		Figure 1 shows that the SCF complex (Cul1 and Skp1) is required for Ku80 ubiquitylation. Ku80 is the initiating factor of nonhomologous end joining double-strand break repair. When polyubiquitylated, Ku80 dissociates from the DNA where the break was. Figure 4 (an immunoprecipitation) shows that when Fbxl2 is not present, the binding of Cul1 and Skp1 is inhibited and there are less modifications to Ku80. This proves that Fbx12 is the protein that recruits the SCF to double stranded breaks.	complete CACAO 9796
	GO:0003677	DNA binding	PMID:23324393	ECO:0000314			F		See Table 1 and Figure 2.	complete CACAO 9907
involved_in	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	PMID:23324393	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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References

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