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VIBPA:VOPS

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Species (Taxon ID) Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633). (223926)
Gene Name(s) vopS
Protein Name(s) Adenosine monophosphate-protein transferase VopS

AMPylator VopS Vibrio outer protein S

External Links
UniProt Q87P32
EMBL BA000031
RefSeq NP_798065.1
PDB 3LET
PDBsum 3LET
STRING 223926.VP1686
EnsemblBacteria BAC59949
GeneID 1189193
KEGG vpa:VP1686
PATRIC 20141546
HOGENOM HOG000290317
OMA HGFTDGN
OrthoDB EOG6G4VRM
BioCyc VPAR223926:GHK4-1737-MONOMER
Proteomes UP000002493
GO GO:0005576
GO:0005524
GO:0070733
GO:0048365
GO:0006464
GO:0034259
GO:0035024
GO:0009405
GO:0018178
GO:0018117
GO:0043088
GO:0044054
InterPro IPR003812
Pfam PF02661
SUPFAM SSF140931
PROSITE PS51459

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0048365

Rac GTPase binding

PMID:19039103[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044054

rounding by symbiont of host cells

PMID:19039103[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

PMID:19039103[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035024

negative regulation of Rho protein signal transduction

PMID:19039103[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018178

peptidyl-threonine adenylylation

PMID:19039103[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070733

protein adenylyltransferase activity

PMID:20410310[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070733

protein adenylyltransferase activity

PMID:19039103[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034260

negative regulation of GTPase activity

PMID:19039103[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018117

protein adenylylation

PMID:20410310[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:19039103[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006464

cellular protein modification process

PMID:19039103[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0548

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Yarbrough, ML et al. (2009) AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science 323 269-72 PubMed GONUTS page
  2. 2.0 2.1 Luong, P et al. (2010) Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. J. Biol. Chem. 285 20155-63 PubMed GONUTS page