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VIBHB:LUXO

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Species (Taxon ID) Vibrio harveyi (strain ATCC BAA-1116 / BB120). (338187)
Gene Name(s) luxO
Protein Name(s) Luminescence regulatory protein LuxO
External Links
UniProt A7MVC2
EMBL CP000789
RefSeq YP_001446139.1
ProteinModelPortal A7MVC2
STRING 338187.VIBHAR_02959
EnsemblBacteria ABU71912
GeneID 5554621
KEGG vha:VIBHAR_02959
PATRIC 20132574
eggNOG COG2204
HOGENOM HOG000058489
KO K10912
OMA VIRNVVV
OrthoDB EOG6WHNMG
ProtClustDB CLSK874182
BioCyc VHAR338187:GJCH-2949-MONOMER
GO GO:0005524
GO:0017111
GO:0000156
GO:0043565
GO:0035556
GO:0006355
GO:0006351
Gene3D 1.10.10.60
InterPro IPR003593
IPR011006
IPR009057
IPR002197
IPR027417
IPR001789
IPR002078
IPR025943
IPR025944
Pfam PF02954
PF00072
PF00158
SMART SM00382
SM00448
SUPFAM SSF46689
SSF52172
SSF52540
PROSITE PS50110
PS00675
PS00676
PS00688
PS50045

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008218

bioluminescence

PMID:8065259[1]

ECO:0000315

P

Figure 2. Response phenotypes of transposon insertion mutants of V. harveyi. The mutant strains showed less bioluminescence activity compared to the wild type. The results confirmed that insertion of the luxO locus induces luminescence.

complete

GO:0000160

two-component signal transduction system (phosphorelay)

PMID:8065259[1]

ECO:0000247

UniProtKB:A7MVC2


P

Figure 4. Amino acid sequence comparisons between LuxO and members of bacterial two component sensory transduction system showed similarities. Therefore, LuxO plays a role in the two component sensory system.

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17234887[2]

ECO:0005676

ad-hoc quantitative phenotype observation evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-dependent

PMID:10027982[3]

ECO:0000315

P

Fig 2 A&B: At high cell densities, LuxO acts as if unphosphorylated, while at low cell densities, LuxO acts as if phosphorylated and represses luminescence

complete
CACAO 8781

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17234887[2]

ECO:0001808

reverse transcription polymerase chain reaction evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

PMID:10027982[3]

ECO:0000315

P

Fig 2: At high cell densities, LuxO acts as if de-phosphorylated, while at low cell densities, LuxO acts as if phosphorylated and represses luminescence.

complete
CACAO 9004

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001789

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002078

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002078

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002078

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002197

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bassler, BL et al. (1994) Sequence and function of LuxO, a negative regulator of luminescence in Vibrio harveyi. Mol. Microbiol. 12 403-12 PubMed GONUTS page
  2. 2.0 2.1 Tu, KC & Bassler, BL (2007) Multiple small RNAs act additively to integrate sensory information and control quorum sensing in Vibrio harveyi. Genes Dev. 21 221-33 PubMed GONUTS page
  3. 3.0 3.1 Freeman, JA & Bassler, BL (1999) A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi. Mol. Microbiol. 31 665-77 PubMed GONUTS page