VIBF1:Q5E5B9

Species (Taxon ID)	Vibrio fischeri (strain ATCC 700601 / ES114). (312309)
Gene Name(s)	pepN (ECO:0000313 with EMBL:AAW85777.1)
Protein Name(s)	Aminopeptidase N (ECO:0000313 with EMBL:AAW85777.1)
External Links
UniProt	Q5E5B9
EMBL	CP000020
RefSeq	WP_011261889.1 YP_204665.1
ProteinModelPortal	Q5E5B9
SMR	Q5E5B9
STRING	312309.VF_1282
MEROPS	M01.005
EnsemblBacteria	AAW85777
GeneID	3278662
KEGG	vfi:VF_1282
PATRIC	20113180
eggNOG	COG0308
HOGENOM	HOG000257670
KO	K01256
OMA	MIVAVND
OrthoDB	EOG693GJ0
BioCyc	AFIS312309:GIWP-1345-MONOMER
Proteomes	UP000000537
GO	GO:0004177 GO:0008237 GO:0008270
Gene3D	1.25.50.10
InterPro	IPR001930 IPR014782 IPR012779 IPR024601
PANTHER	PTHR11533
Pfam	PF11940 PF01433
PRINTS	PR00756
TIGRFAMs	TIGR02414

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004177	aminopeptidase activity	PMID:22636772	ECO:0000315			F		Fig. 3 shows the pepN mutant strains had delayed colonization of the squid light organ, which was corrected when pepN was expressed on a plasmid.	complete CACAO 8614
	GO:0070006	metalloaminopeptidase activity	PMID:22636772	ECO:0000314			F		Fig. 1 shows the enzyme's activity was much greater in whole cells compared to cell-free supernatant, thus suggesting activity is cell-associated and not secreted.	complete CACAO 8616
	GO:0005737	cytoplasm	PMID:22636772	ECO:0000314			C		Table 2 shows the majority of the protein's activity is in the cytoplasm with substantial activity in the cell membrane. The protein is considered to be cytosolic with close association to the membrane.	complete CACAO 8618
	GO:0070006	metalloaminopeptidase activity	PMID:22636772	ECO:0000315			F		Table 2. demonstrates the impaired ability of the pepN mutant to metabolize an aminopeptidase substrate. It also shows that expression of pepN on pVSV105 restored aminopeptidase activity of the mutant cells to higher degree than the wild-type.	complete CACAO 8684
enables	GO:0070006	metalloaminopeptidase activity	PMID:22636772	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22636772	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070006	metalloaminopeptidase activity	PMID:22636772	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001930	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014782	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012779 InterPro:IPR014782	F		Seeded From UniProt	complete
enables	GO:0004177	aminopeptidase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0031	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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