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VIBC3:TCPN

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Species (Taxon ID) Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /O395). (345073)
Gene Name(s) tcpN (synonyms: toxT)
Protein Name(s) TCP pilus virulence regulatory protein
External Links
UniProt A5F384
EMBL AF325733
CP000627
CP001235
RefSeq YP_001216319.1
YP_002819105.1
PDB 3GBG
PDBsum 3GBG
ProteinModelPortal A5F384
STRING 345073.VC0395_A0363
EnsemblBacteria ABQ20018
ACP08869
GeneID 5136424
7774854
KEGG vco:VC0395_A0363
vcr:VC395_0854
eggNOG COG2207
KO K10923
OMA INQLPPM
EvolutionaryTrace A5F384
Proteomes UP000000249
UP000001630
GO GO:0005737
GO:0043565
GO:0003700
GO:0009405
GO:0006351
Gene3D 1.10.10.60
InterPro IPR009057
IPR018060
IPR018062
IPR020449
Pfam PF00165
PRINTS PR00032
SMART SM00342
SUPFAM SSF46689
PROSITE PS00041
PS01124

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:11849541[1]

ECO:0001204

in vitro transcription assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:22821976[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:16553883[3]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:16291662[4]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:15853890[5]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:11849541[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_009456.1

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:22821976[2]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009456.1

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:16553883[3]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009457.1

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:15853890[5]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009457.1

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:22821976[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:11849541[1]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:22821976[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:22821976[2]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009456.1

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:22821976[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:16553883[3]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:16291662[4]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:15853890[5]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:11849541[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_009456.1

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:16553883[3]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009457.1

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:15853890[5]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009457.1

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:11849541[1]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:22821976[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:16553883[3]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:16291662[4]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:15853890[5]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:11849541[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_009456.1

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:22821976[2]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009456.1

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:16553883[3]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009457.1

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:15853890[5]

ECO:0005626

copper-phenanthroline footprinting evidence used in manual assertion

RefSeq:NC_009457.1

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:22821976[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:11849541[1]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001217

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018060
InterPro:IPR018062
InterPro:IPR020449

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018060
InterPro:IPR018062
InterPro:IPR020449

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018060
InterPro:IPR018062

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Yu, RR & DiRita, VJ (2002) Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation. Mol. Microbiol. 43 119-34 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Dittmer, JB & Withey, JH (2012) Identification and characterization of the functional toxboxes in the Vibrio cholerae cholera toxin promoter. J. Bacteriol. 194 5255-63 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Withey, JH & DiRita, VJ (2006) The toxbox: specific DNA sequence requirements for activation of Vibrio cholerae virulence genes by ToxT. Mol. Microbiol. 59 1779-89 PubMed GONUTS page
  4. 4.0 4.1 4.2 Withey, JH & Dirita, VJ (2005) Vibrio cholerae ToxT independently activates the divergently transcribed aldA and tagA genes. J. Bacteriol. 187 7890-900 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Withey, JH & DiRita, VJ (2005) Activation of both acfA and acfD transcription by Vibrio cholerae ToxT requires binding to two centrally located DNA sites in an inverted repeat conformation. Mol. Microbiol. 56 1062-77 PubMed GONUTS page