VIBC3:TCPN

Species (Taxon ID)	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /O395). (345073)
Gene Name(s)	tcpN (synonyms: toxT)
Protein Name(s)	TCP pilus virulence regulatory protein
External Links
UniProt	A5F384
EMBL	AF325733 CP000627 CP001235
RefSeq	YP_001216319.1 YP_002819105.1
PDB	3GBG
PDBsum	3GBG
ProteinModelPortal	A5F384
STRING	345073.VC0395_A0363
EnsemblBacteria	ABQ20018 ACP08869
GeneID	5136424 7774854
KEGG	vco:VC0395_A0363 vcr:VC395_0854
eggNOG	COG2207
KO	K10923
OMA	INQLPPM
EvolutionaryTrace	A5F384
Proteomes	UP000000249 UP000001630
GO	GO:0005737 GO:0043565 GO:0003700 GO:0009405 GO:0006351
Gene3D	1.10.10.60
InterPro	IPR009057 IPR018060 IPR018062 IPR020449
Pfam	PF00165
PRINTS	PR00032
SMART	SM00342
SUPFAM	SSF46689
PROSITE	PS00041 PS01124

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11849541^[1]	ECO:0001204	in vitro transcription assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:22821976^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:16553883^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:16291662^[4]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:15853890^[5]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:11849541^[1]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_009456.1	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:22821976^[2]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009456.1	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:16553883^[3]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009457.1	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:15853890^[5]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009457.1	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:22821976^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:11849541^[1]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:22821976^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:22821976^[2]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009456.1	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:22821976^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:16553883^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:16291662^[4]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:15853890^[5]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:11849541^[1]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_009456.1	F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:16553883^[3]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009457.1	F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:15853890^[5]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009457.1	F	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:11849541^[1]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:22821976^[2]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:16553883^[3]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:16291662^[4]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:15853890^[5]	ECO:0005667	site-directed mutagenesis phenotypic evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:11849541^[1]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_009456.1	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:22821976^[2]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009456.1	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:16553883^[3]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009457.1	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:15853890^[5]	ECO:0005626	copper-phenanthroline footprinting evidence used in manual assertion	RefSeq:NC_009457.1	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:22821976^[2]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:11849541^[1]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001217	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001217	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018060 InterPro:IPR018062 InterPro:IPR020449	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018060 InterPro:IPR018062 InterPro:IPR020449	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018060 InterPro:IPR018062	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Yu, RR & DiRita, VJ (2002) Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation. Mol. Microbiol. 43 119-34 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Dittmer, JB & Withey, JH (2012) Identification and characterization of the functional toxboxes in the Vibrio cholerae cholera toxin promoter. J. Bacteriol. 194 5255-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Withey, JH & DiRita, VJ (2006) The toxbox: specific DNA sequence requirements for activation of Vibrio cholerae virulence genes by ToxT. Mol. Microbiol. 59 1779-89 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Withey, JH & Dirita, VJ (2005) Vibrio cholerae ToxT independently activates the divergently transcribed aldA and tagA genes. J. Bacteriol. 187 7890-900 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Withey, JH & DiRita, VJ (2005) Activation of both acfA and acfD transcription by Vibrio cholerae ToxT requires binding to two centrally located DNA sites in an inverted repeat conformation. Mol. Microbiol. 56 1062-77 PubMed GONUTS page

[PMID:11849541-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Yu, RR & DiRita, VJ (2002) Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation. Mol. Microbiol. 43 119-34 PubMed GONUTS page

[PMID:22821976-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Dittmer, JB & Withey, JH (2012) Identification and characterization of the functional toxboxes in the Vibrio cholerae cholera toxin promoter. J. Bacteriol. 194 5255-63 PubMed GONUTS page

[PMID:16553883-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Withey, JH & DiRita, VJ (2006) The toxbox: specific DNA sequence requirements for activation of Vibrio cholerae virulence genes by ToxT. Mol. Microbiol. 59 1779-89 PubMed GONUTS page

[PMID:16291662-4] 4.0 ^4.1 ^4.2 Withey, JH & Dirita, VJ (2005) Vibrio cholerae ToxT independently activates the divergently transcribed aldA and tagA genes. J. Bacteriol. 187 7890-900 PubMed GONUTS page

[PMID:15853890-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Withey, JH & DiRita, VJ (2005) Activation of both acfA and acfD transcription by Vibrio cholerae ToxT requires binding to two centrally located DNA sites in an inverted repeat conformation. Mol. Microbiol. 56 1062-77 PubMed GONUTS page

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VIBC3:TCPN

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