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UROYA:KAX6L

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Species (Taxon ID) Urodacus yaschenkoi (Inland robust scorpion). (1273102)
Gene Name(s) No Information Provided.
Protein Name(s) Potassium channel toxin alpha-KTx 6.21

Urotoxin

External Links
UniProt P0DL37
GO GO:0005576
GO:0008200
GO:0006952
GO:0009405
Gene3D 3.30.30.10
InterPro IPR003614
IPR001947
Pfam PF00451
PRINTS PR00286
ProDom PD003586
SUPFAM SSF57095

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0044361

envenomation resulting in modulation of transmission of nerve impulse in other organism

PMID:24723491[1]

ECO:0000314

P

Figure 5 shows the inhibition of current through the hKv1.1 channel by purified urotoxin. Figure 5, panel B shows the dose-dependent manner of inhibition. Figure 5 panel C shows that this is reversible and current is restored after urotoxin is no longer applied.

complete
CACAO 10878

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001947

C

Seeded From UniProt

complete

enables

GO:0008200

ion channel inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001947

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001947

P

Seeded From UniProt

complete

enables

GO:0090729

toxin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0800

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Luna-Ramírez, K et al. (2014) Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi. Mol. Pharmacol. 86 28-41 PubMed GONUTS page