THEMA:Q9X1X0

Species (Taxon ID)	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099). (243274)
Gene Name(s)	No Information Provided.
Protein Name(s)	Exonuclease, putative (ECO:0000313 with EMBL:AAD36702.1) Uncharacterized protein (ECO:0000313 with EMBL:AHD18468.1)
External Links
UniProt	Q9X1X0
EMBL	AE000512 CP007013
PIR	C72230
RefSeq	NP_229435.1 WP_010865373.1 YP_008991271.1
PDB	2Q8U 3QF7 3QG5 3THN 3THO 4NZV 4O24 4O43 4O4K 4O5G 4W9M
PDBsum	2Q8U 3QF7 3QG5 3THN 3THO 4NZV 4O24 4O43 4O4K 4O5G 4W9M
STRING	243274.TM1635
EnsemblBacteria	AAD36702 AHD18468
GeneID	897574
KEGG	tma:TM1635 tmi:THEMA_06070
PATRIC	23938244
KO	K03547
OMA	DLFDNFN
OrthoDB	EOG60CWP4
BioCyc	TMAR243274:GC6P-1681-MONOMER
Proteomes	UP000008183
GO	GO:0000785 GO:0030870 GO:0035861 GO:0008408 GO:0004519 GO:0046872 GO:0006284 GO:0006302 GO:0090305 GO:0006289 GO:0000723
Gene3D	3.60.21.10
InterPro	IPR004843 IPR029052 IPR004593 IPR026843
Pfam	PF00149 PF12320
SUPFAM	SSF56300
TIGRFAMs	TIGR00619

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003677	exonuclease activity	PMID:21937514	ECO:0000315			F		Figure 4: A comparison of DNA affinity for two versions of the proposed exonuclease using EMSA (elecrophoretic mobility shift assay). When starved of ATP, TmMRE loses affinity for DNA binding. MRE requires dimerization followed by ATP hydrolysis to perform exonuclease activity. Figure 5: Schematic of DNA binding mechanism via the Antibody DNA-binding Assay. These results allowed the researchers to conclude with confidence taht Q9X1X0 is a DNA-binding and exonuclease protein.	complete CACAO 10956
enables	GO:0003677	DNA binding	PMID:21937514	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004527	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004593	F		Seeded From UniProt	complete
involved_in	GO:0006259	DNA metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004593	P		Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004593	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004843	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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