GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0060341 | regulation of cellular localization | PMID:15221008 | IMP: Inferred from Mutant Phenotype | P | ||||
| This annotation made on page: MOUSE:THOC5 By: Kohli3 (group Team WhiteShyPaulCo) on 2013-11-04 16:06:52 CST. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Akreda, Team Stones Throw | 2013-11-17 12:55:12 CST | Figure 4b. Replacement of serine residues 5 and 6 with alanine leads to the nuclear location of FMIP and replacement with glutamate leads to the cytoplasmic location independent of co-expression of PKCalpha. When serine 5 or 6 was replaced by alanine, the rate of phosphorylation was significantly reduced to about 50% of control values, and, when both serines were mutated, FMIP was no longer detectably phosphorylated by PKC. Furthermore, FMIPSS5,6AA was detected exclusively in the nucleus, while FMIPSS5,6EE mimicking phosphorylated FMIP was detected exclusively in the cytoplasm, independent of the presence of PKCalpha. These data suggest that PKC action influences FMIP subcellular localization | 0 |
| Private Assessment | Suzialeksander | 2013-12-12 12:38:46 CST | You need to be an instructor to view these notes. | Updated by Instructor ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Private Assessment | Suzialeksander | 2013-11-18 11:10:26 CST | You need to be an instructor to view these notes. | Requires Changes |
| Public Assessment | DanielRenfro | 2013-11-17 12:55:12 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Bmcintosh | 2013-11-15 10:11:10 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✔ With/From ✗ Notes ✔ Unique/Original |
