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Cacao

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GO:0140133negative regulation by symbiont of host cytokine secretionPMID:23083102IMP: Inferred from Mutant Phenotype P
This annotation made on page: SHIFL:IPA4
By: JonathanMarcias (group Team SEAL Team Ricks) on 2017-11-16 18:47:58 CST.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
Private
Assessment
Suzialeksander2017-11-27 14:48:24 CSTYou need to be an instructor to view these notes.Acceptable
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Public
Assessment
DanielRenfro2017-11-21 08:35:29 CST

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0052083 negative regulation by symbiont of host cell-mediated immune response PMID:23083102 IMP: Inferred from Mutant Phenotype P Organism: Shigella flexneri

protein: IPA4 but called IPAH4.5 in paper. Fig 2C: Wild type IPA4 shows a lower cytokine production in the host when compared to delta IPA4 and the mutated IPA4 thus showing negative regulation of cytokine secretion by the symbiont (s. flexneri). The modulation of cytokine production is proved by the mutant, which has a higher cytokine production than the wild type IPA4. Cytokine production is part of the cell mediated immune response in the host meaning that IPA4 is negatively regulating the response. ||complete
CACAO 13018

on SHIFL:IPA4
Flagged
Private
Assessment
Suzialeksander2017-11-20 14:41:06 CSTYou need to be an instructor to view these notes.Requires Changes
Go term
Notes
Public
Assessment
DanielRenfro2017-11-19 17:33:26 CST

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0140133 negative regulation by symbiont of host cytokine secretion PMID:23083102 IMP: Inferred from Mutant Phenotype P Organism: Shigella flexneri

protein: IPA4 Fig 2C: Wild type IPA4 shows a lower cytokine production in the host when compared to delta IPA4 and the mutated IPA4 thus showing negative regulation of cytokine secretion by the symbiont (s. flexneri). The modulation of cytokine production is proved by the mutant, which has a higher cytokine production than the wild type IPA4. ||complete
CACAO 13018

on SHIFL:IPA4
Flagged
Private
Assessment
Suzialeksander2017-11-17 15:06:49 CSTYou need to be an instructor to view these notes.Requires Changes
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Public
Assessment
Suzialeksander2017-11-17 14:57:49 CST

WHAT ARE THE REQUIRED COMPONENTS OF A CACAO ANNOTATION?

Requires Changes
Notes