GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0010468 | regulation of gene expression | PMID:28262547 | IMP: Inferred from Mutant Phenotype | P | ||||
| This annotation made on page: MOUSE:KLF4 By: SStone15 (group Team Lily Whale) on 2017-04-04 13:35:19 CDT. | ||||||||
You must be logged in to challenge this annotation.
| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Challenge | SStone15, Team Lily Whale | 2017-04-21 14:46:58 CDT | GO:0045944 positive regulation of transcription from RNA polymerase II promoter // MOUSE KLF4 // "qRT-PCR showed that the high level of KLF4 or expression of exogenous TCL1 in iPSCs(Low-K) is accompanied by increased mRNA expression levels of glucose transporter (Glut1), pyruvate kinase M2 (Pkm2), and lactate dehydrogenase A (Ldha) ( Figure 6F)." KLF4 upregulates Tcl1 expression to enhance AKT activity, thus increasing the expression of other glycolytic protein. | 2 | ||||||||||||||||||
| Challenge | CSears, Team Girl, you trypsin | 2017-04-18 14:13:52 CDT | GO:0045821 positive regulation of glycolytic process Figure 4C and 4D: Cells expressing higher levels of mouse KLF4 show increased glucose uptake and lactate production due to increased glycolytic activity as compared to cells expressing low levels of KLF4, which is counteracted by treatment of an AKT inhibitor. IMP. | 0 | ||||||||||||||||||
| Private Assessment | Suzialeksander | 2017-06-13 16:41:43 CDT | You need to be an instructor to view these notes. | Updated by Instructor | ||||||||||||||||||
| Private Assessment | Suzialeksander | 2017-04-25 15:43:08 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✗ Evidence ✔ With/From ✗ Notes ✔ Unique/Original | ||||||||||||||||||
| Public Assessment | DanielRenfro | 2017-04-22 16:58:13 CDT | This annotation has been flagged because it has been edited since last assessment
| Flagged | ||||||||||||||||||
| Private Assessment | Suzialeksander | 2017-04-21 16:03:30 CDT | You need to be an instructor to view these notes. | Requires Changes | ||||||||||||||||||
| Private Assessment | Suzialeksander | 2017-04-21 15:20:47 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Go term | ||||||||||||||||||
| Public Assessment | DanielRenfro | 2017-04-21 14:46:58 CDT | This annotation has been flagged because it has been challenged since last assessment | Flagged | ||||||||||||||||||
| Public Assessment | DanielRenfro | 2017-04-18 14:13:52 CDT | This annotation has been flagged because it has been challenged since last assessment | Flagged | ||||||||||||||||||
| Private Assessment | Sandyl 27 | 2017-04-05 11:14:49 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Publication ✔ Qualifier ✗ Go term ✔ With/From ✗ Notes ✔ Unique/Original |
