GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway | PMID:23071095 | IDA: Inferred from Direct Assay | P | ||||
| This annotation made on page: MOUSE:CRERF By: Henke01 (group Team RumRod) on 2014-10-08 12:18:53 CDT. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Min.lorna, Team Groot | 2014-10-26 19:21:18 CDT | Evidence code： IMP - determined function of LRF by comparing corticosterone levels in wildtype and mutant mice GR = glucocorticoid receptor Notes： Fig. 6C - GR activates transcription of pMMTV-luc reporter, transcription activation occurred to a lesser extent when LRF was added - this indicates LRF reduces GR activity Fig. 6D - GR levels decreased in cell over time in the presence of LRF, increased over time in the presence of LRF - this indicates LRF degrades GR | 8 |
| Private Assessment | Suzialeksander | 2014-12-17 15:02:46 CST | You need to be an instructor to view these notes. | Updated by Instructor |
| Private Assessment | Suzialeksander | 2014-10-28 15:47:57 CDT | You need to be an instructor to view these notes. | Corrected Through Challenges ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | DanielRenfro | 2014-10-26 19:21:18 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:1900170||negative regulation of glucocorticoid mediated signaling pathway||PMID:23071095||IDA: Inferred from Direct Assay||||P||Fig.2, LRF-1- females displayed evidence of maternal neglect including infantcide. Fig.3 defect in PRL secretion in LRF-1- females, normal pattern of circulating PRL was not seen in LRF-1- females. Fig.4 PRL signaling pathway affected in LRF-1- females. Fig.6 LRF is a negative regulator of the glucocorticoid receptor, also possible that LRF may regulate prolactin signaling through GR||complete | Flagged |
| Private Assessment | Suzialeksander | 2014-10-22 12:57:35 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✗ Evidence ✔ With/From ✗ Notes ✔ Unique/Original |
| Private Assessment | Suzialeksander | 2014-10-10 15:05:41 CDT | You need to be an instructor to view these notes. | Flagged |
