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The row for this annotation cannot be found. This might be due to a row or page getting deleted.

GO:0010646regulation of cell communicationPMID:24700869IMP: Inferred from Mutant Phenotype P
This annotation made on page:
By: Krugcary (group MichSt14A 39) on 2014-04-06 15:11:52 CDT.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeRdesai525,
Team Texas Aggies
2014-04-08 19:38:58 CDT

UniProt accession described corresponds to uncharacterized protein in chicken, however, the experimental model is mice. Thus correct UniProt accession should be: Q0HA38. GO:0045879 (negative regulation of smoothened signaling pathway) is a synonymy of "down regulation of smoothened signaling pathway" and "Sonic hedgehog signaling pathway". Thus, this is a more appropriate GO term.

Notes: Figure 1: Thm1(Ttc21b), negatively regulates Hedgehog signaling, and loss of THM1, in mutant mouse, causes renal cysts disease which than causes kidney failure in mice.

The evidence code IMP is appropriate.

3
Private
Assessment
Suzialeksander2014-05-21 13:25:12 CDTYou need to be an instructor to view these notes.Unacceptable
Private
Assessment
Suzialeksander2014-04-21 13:32:23 CDTYou need to be an instructor to view these notes.Requires Changes
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Public
Assessment
DanielRenfro2014-04-08 19:38:58 CDT

This annotation has been flagged because it has been edited since last assessment ||GO:0010646||regulation of cell communication||PMID:24700869||IMP: Inferred from Mutant Phenotype||||P||||complete

Flagged
Private
Assessment
Suzialeksander2014-04-07 14:05:37 CDTYou need to be an instructor to view these notes.Requires Changes
Notes