SULSO:CAS4

Species (Taxon ID)	Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 /P2). (273057)
Gene Name(s)	cas4
Protein Name(s)	CRISPR-associated exonuclease Cas4
External Links
UniProt	Q97TX9
EMBL	AE006641
PIR	A90139
RefSeq	NP_341578.1 WP_009989652.1
PDB	4IC1
PDBsum	4IC1
STRING	273057.SSO0001
EnsemblBacteria	AAK43340
GeneID	1455258
KEGG	sso:SSO0001
eggNOG	COG1468
HOGENOM	HOG000223327
InParanoid	Q97TX9
KO	K07464
OMA	WECRYCP
BioCyc	SSOL273057:GCH2-1-MONOMER
Proteomes	UP000001974
GO	GO:0051539 GO:0003677 GO:0030145 GO:0045145 GO:0051607 GO:0000738 GO:0032508
InterPro	IPR013343
TIGRFAMs	TIGR00372

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity	PMID:23056615	ECO:0000314			F		Figures 4,5- the exonuclease activity of the gene was studied. A DNA oligonucleotide substrate was labeled at the 5' and 3' terminus with fluorescence. When labeled at the 5' end, the product had a size of around 4 nucleotides, while the 3' end had products that got progressively smaller until they reached 1-2 nucleotides in length. This shows that the gene is involved in the 5' to 3' exodeoxyribonuclease activity and initiates cleavage at the 5' end.	complete CACAO 9333
enables	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity	PMID:23056615	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030145	manganese ion binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000738	DNA catabolic process, exonucleolytic		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F		Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
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References

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