STRTR:E7AXS8

Species (Taxon ID)	Streptococcus thermophilus. (1308)
Gene Name(s)	hdcA (ECO:0000313 with EMBL:CBX24604.1)
Protein Name(s)	HdcA protein (ECO:0000313 with EMBL:CBX24604.1)
External Links
UniProt	E7AXS8
EMBL	FR693807
ProteinModelPortal	E7AXS8
GO	GO:0004398 GO:0006547
Gene3D	3.50.20.10 4.10.510.10
InterPro	IPR003427 IPR016004 IPR016106 IPR016104 IPR016105
Pfam	PF02329
PIRSF	PIRSF001341
SUPFAM	SSF56271
TIGRFAMs	TIGR00541

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004398	histidine decarboxylase activity	PMID:22429258	ECO:0000270			F		Figure 2A shows that at the pH values 7.0, 6.2, and 5.5 the OD600 rapidly increased between 8 and 24 h of incubation reaching at 48 h the maximum values, corresponding to cell concentrations between 9.2 and 8.8 log CFU/mL. Also, in Figure in 3A, histamine rapidly accumulated at pH 7.0, 6.2, and 5.5 and a maximum concentration of about 350 mg/L was reached after 24 h. In both cases the production of histamine increased concomitantly with the cell number with a relatively small further rise during the stationary phase. In all cultures the maximum histamine levels were reached at the end of active growth. Histamine was detectable (10 to 55 mg/L) even when growth was strongly inhibited.The HdcA decarboxylase of this strain is very active since the exponential phase under different conditions characterizing the 1st step of the cheesemaking process. In addition, the enzyme is even more active outside the cells and its action is not significantly limited by the conditions found during the cheese ripening process. In this framework, the death and lysis of the starter cultures can be a factor which strengthens the risk of histamine accumulation during cheese ripening when temperature, pH, and NaCl concentration allow an intense activity of this HdcA enzyme.	complete CACAO 4004
enables	GO:0004398	histidine decarboxylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003427 InterPro:IPR016106	F		Seeded From UniProt	complete
involved_in	GO:0006520	cellular amino acid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016104 InterPro:IPR016105	P		Seeded From UniProt	complete
involved_in	GO:0006547	histidine metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003427	P		Seeded From UniProt	complete
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016104 InterPro:IPR016105	F		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
enables	GO:0016831	carboxy-lyase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0210	F		Seeded From UniProt	complete
involved_in	GO:0006547	histidine metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000397758	P		Seeded From UniProt	complete
enables	GO:0004398	histidine decarboxylase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000397758	F		Seeded From UniProt	complete
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References

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