STRSU:A0A142UME2

Species (Taxon ID)	Streptococcus suis. (1307)
Gene Name(s)	uxuA (ECO:0000256 with HAMAP-Rule:MF_00106)
Protein Name(s)	Mannonate dehydratase (ECO:0000256 with HAMAP-Rule:MF_00106, ECO:0000256 with SAAS:SAAS00651377) D-mannonate hydro-lyase (ECO:0000256 with HAMAP-Rule:MF_00106)
External Links
UniProt	A0A142UME2
EMBL	CP012911
RefSeq	WP_002938047.1
ProteinModelPortal	A0A142UME2
UniPathway	UPA00246
Proteomes	UP000070276
GO	GO:0008927 GO:0006064
Gene3D	3.20.20.150
HAMAP	MF_00106
InterPro	IPR004628 IPR013022
Pfam	PF03786
SUPFAM	SSF51658

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008927	mannonate dehydratase activity	PMID:19617363	ECO:0000315			F		Based on fig. 1 (mass spec), two dominant peaks were found after incubation with mannonate dehydratase(ManD). The first peak corresponds to remaining substrate(D-mannonate), whereas the second peak is consistent with formation of the expected protonated dehydration product, 2-KDG (IDA inferred) Based on table 2, wild type ManD show high affinity to the substrate but the mutant protein Y325F was catalytically inactive while the activity of H311A was only 2.4% that of the native enzyme. The results of site-directed mutagenesis confirmed the functional of these residues in the dehydration reaction (IMP inferred)	complete CACAO 4480
enables	GO:0008927	mannonate dehydratase activity	PMID:19617363	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006064	glucuronate catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004628	P		Seeded From UniProt	complete
enables	GO:0008927	mannonate dehydratase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004628	F		Seeded From UniProt	complete
enables	GO:0008927	mannonate dehydratase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.1.8	F		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
enables	GO:0008927	mannonate dehydratase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000034424	F		Seeded From UniProt	complete
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References

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