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STRR6:MUTX

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Species (Taxon ID) Streptococcus pneumoniae (strain ATCC BAA-255 / R6). (171101)
Gene Name(s) mutX
Protein Name(s) 8-oxo-dGTP diphosphatase

8-oxo-dGTPase 7,8-dihydro-8-oxoguanine-triphosphatase Mutator protein MutT dGTP pyrophosphohydrolase

External Links
UniProt P59659
EMBL AE007317
RefSeq NP_358648.1
ProteinModelPortal P59659
STRING 171101.spr1054
EnsemblBacteria AAK99858
GeneID 933037
KEGG spr:spr1054
PATRIC 19702058
eggNOG COG0494
HOGENOM HOG000261966
KO K03574
OMA MPYTPIV
OrthoDB EOG64JFTK
BioCyc SPNE171101:GJC8-1066-MONOMER
Proteomes UP000000586
GO GO:0008413
GO:0046872
GO:0006281
GO:0006260
Gene3D 3.90.79.10
InterPro IPR003562
IPR020476
IPR020084
IPR000086
IPR015797
Pfam PF00293
PRINTS PR01402
PR00502
SUPFAM SSF55811
PROSITE PS51462
PS00893

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008413

8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

PMID:8163538[1]

ECO:0000314

F

Figure 3A: Determination of the products of MutT and MutX reactions. Radiolabeled dGTP was digested by MutX into dGMP.

complete

enables

GO:0016787

hydrolase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000511346
UniProtKB:O86062

F

Seeded From UniProt

complete

enables

GO:0008413

8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002534012
UniProtKB:P59659

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000511346
TAIR:locus:2147665

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003562

P

Seeded From UniProt

complete

enables

GO:0008413

8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003562

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000086
InterPro:IPR015797
InterPro:IPR020084

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Bullions, LC et al. (1994) Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity. J. Biol. Chem. 269 12339-44 PubMed GONUTS page
  2. 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page