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STRPY:Q5R2E0
Contents
| Species (Taxon ID) | Streptococcus pyogenes. (1314) | |
| Gene Name(s) | nga (ECO:0000313 with EMBL:BAD77792.1) | |
| Protein Name(s) | NADase (ECO:0000313 with EMBL:BAD77792.1) | |
| External Links | ||
| UniProt | Q5R2E0 | |
| EMBL | AB128036 | |
| STRING | 160490.SPy_0165 | |
| PaxDb | Q5R2E0 | |
| SABIO-RK | Q5R2E0 | |
| Gene3D | 2.60.120.260 | |
| InterPro | IPR008979 IPR010900 | |
| Pfam | PF07461 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
Contributes to |
GO:0008219 |
cell death |
ECO:0000315 |
P |
NADase acts synergistically with SLO to cause cell death in all essentially all of the cells they infect. Mutant forms of the protein only caused cell death in less then 10% of the infected cells. |
complete | ||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Chandrasekaran, S & Caparon, MG (2016) The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD⁺ Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis. MBio 7 e02215-15 PubMed GONUTS page
