STRP3:TACY

Species (Taxon ID)	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315). (198466)
Gene Name(s)	slo
Protein Name(s)	Streptolysin O Thiol-activated cytolysin
External Links
UniProt	P0DF96
EMBL	M18638 AE014074
PIR	A43507
RefSeq	NP_663934.1 WP_010921831.1
ProteinModelPortal	P0DF96
SMR	P0DF96
EnsemblBacteria	AAM78737
GeneID	1008444
KEGG	spg:SpyM3_0130
HOGENOM	HOG000056095
KO	K11031
OMA	THKTWDG
OrthoDB	EOG6S7XT6
BioCyc	SPYO198466:GJDL-180-MONOMER
Proteomes	UP000000564
GO	GO:0020002 GO:0016021 GO:0015485 GO:0044179 GO:0009405
Gene3D	3.90.840.10
InterPro	IPR001869
Pfam	PF01289
PRINTS	PR01400
SUPFAM	SSF56978
PROSITE	PS00481

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019835	cytolysis	PMID:13952054	ECO:0000314			P		Figure 5A and 5B These experiments suggest that the Zn2+-depleted L chain is slowly able to regain its zinc ion from the cytoplasmic pool, while a Zn2+-depleted and DEPC modified one is not, and that bound Zn2+ is necessary.	complete
Contributes to	GO:0008219	cell death	PMID:26838722	ECO:0000315			P		Streptolysin o acts synergistically with NADase+ SPN to destroy cell membranes in infected cells and cause necrosis. In cells infected with mutant types of these proteins less then 10% of the cell membranes were destroyed.	complete CACAO 11362
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001869 InterPro:IPR036359 InterPro:IPR036363	P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001869 InterPro:IPR036359 InterPro:IPR036363	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
involved_in	GO:0044179	hemolysis in other organism	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0354	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1032 UniProtKB-SubCell:SL-0375	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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References

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