STRP1:CAS9

Species (Taxon ID)	Streptococcus pyogenes serotype M1. (301447)
Gene Name(s)	cas9 (ECO:0000255 with HAMAP-Rule:MF_01480) (synonyms: csn1)
Protein Name(s)	CRISPR-associated endonuclease Cas9/Csn1 (ECO:0000255 with HAMAP-Rule:MF_01480) SpyCas9
External Links
UniProt	Q99ZW2
EMBL	AE004092
RefSeq	NP_269215.1
PDB	4CMP 4CMQ 4OO8 4UN3 4UN4 4UN5
PDBsum	4CMP 4CMQ 4OO8 4UN3 4UN4 4UN5
ProteinModelPortal	Q99ZW2
STRING	160490.SPy_1046
EnsemblBacteria	AAK33936
GeneID	901176
KEGG	spy:SPy_1046
PATRIC	19715675
HOGENOM	HOG000071789
KO	K09952
OMA	IPHQIHL
OrthoDB	EOG6MH57S
BioCyc	SPYO160490:GJ81-863-MONOMER
Proteomes	UP000000750
GO	GO:0008408 GO:0003677 GO:0004520 GO:0046872 GO:0003723 GO:0051607 GO:0000737 GO:0043571 GO:0090305
HAMAP	MF_01480
InterPro	IPR028629 IPR025978 IPR003615
Pfam	PF13395
SMART	SM00507
TIGRFAMs	TIGR01865

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0050765	negative regulation of phagocytosis	PMID:26945067	ECO:0000315			P		Streptococcus pyogenes uses Factor H to degrade C3B which is responsible for opsinization. This results in evading phagocytosis.	complete CACAO 11363
involved_in	GO:0043571	maintenance of CRISPR repeat elements		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008408	3'-5' exonuclease activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004520	endodeoxyribonuclease activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008408	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004527	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028629	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165201	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165201	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165201	F		Seeded From UniProt	complete
involved_in	GO:0043571	maintenance of CRISPR repeat elements	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000165201	P		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F		Seeded From UniProt	complete
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References

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