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STRLM:AMY

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Species (Taxon ID) Streptomyces limosus (Streptomyces albidoflavus). (1947)
Gene Name(s) aml
Protein Name(s) Alpha-amylase

1,4-alpha-D-glucan glucanohydrolase

External Links
UniProt P09794
EMBL M18244
ProteinModelPortal P09794
CAZy CBM20
GH13
GO GO:0004556
GO:0046872
GO:2001070
GO:0005975
Gene3D 2.60.40.10
2.60.40.1180
3.20.20.80
InterPro IPR006048
IPR006046
IPR013784
IPR002044
IPR015902
IPR013780
IPR006047
IPR006589
IPR013781
IPR017853
IPR013783
PANTHER PTHR10357
Pfam PF00128
PF02806
PF00686
PRINTS PR00110
SMART SM00642
SM00632
SM01065
SUPFAM SSF49452
SSF51445
PROSITE PS51166

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004556

alpha-amylase activity

PMID:22407721[1]

ECO:0000315

F

To investigate the effect of calcium ion on the thermal stability and activity of BMW-amylase, used site-directed mutagenesis to replace histidine 58 with Asp (D), Ile (I), Tyr (Y), Phe (F), and Arg (R) at the seventh position of EF-hand-like motif.

complete
CACAO 5001

Contributes to

GO:0003824

catalytic activity

PMID:21722880[2]

ECO:0000314

F

Table 3: These results indicated that SF638-1 could inhibit α-amylase within the intestine to reduce blood glucose level.


complete

Contributes to

GO:0003824

catalytic activity

PMID:21722880[2]

ECO:0000315

F

Table 3: These results indicated that SF638-1 could inhibit α-amylase within the intestine to reduce blood glucose level.

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006046
InterPro:IPR006047
InterPro:IPR006048

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006046
InterPro:IPR006047
InterPro:IPR006048

P

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013784

F

Seeded From UniProt

complete

enables

GO:0043169

cation binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006046
InterPro:IPR006048

F

Seeded From UniProt

complete

enables

GO:2001070

starch binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002044

F

Seeded From UniProt

complete

enables

GO:0103025

alpha-amylase activity (releasing maltohexaose)

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.1

F

Seeded From UniProt

complete

enables

GO:0004556

alpha-amylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.2.1.1

F

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Sadeghi, L et al. (2013) Extra EF hand unit (DX) mediated stabilization and calcium independency of α-amylase. Mol. Biotechnol. 53 270-7 PubMed GONUTS page
  2. 2.0 2.1 Meng, P et al. (2011) A novel amino-oligosaccharide isolated from the culture of Streptomyces strain PW638 is a potent inhibitor of α-amylase. Carbohydr. Res. 346 1898-902 PubMed GONUTS page