STREE:Q2XU26

Species (Taxon ID)	Streptococcus pneumoniae. (1313)
Gene Name(s)	ply (ECO:0000313 with EMBL:ABO21352.1)
Protein Name(s)	Pneumolysin (ECO:0000313 with EMBL:ABB53239.1) Thiol-activated cytolysin (ECO:0000313 with EMBL:KGI24225.1)
External Links
UniProt	Q2XU26
EMBL	DQ251177 DQ251179 DQ251181 EF413930 EF413940 EF413941 EF413944 EF413945 EF413946 EF413949 EF413951 EF413952 EF413953 EF413959 GU968217 GU968219 GU968225 GU968228 GU968229 GU968230 GU968233 GU968236 GU968237 GU968238 GU968239 GU968240 GU968241 GU968242 GU968243 GU968246 GU968249 GU968250 GU968251 GU968254 GU968255 GU968256 GU968257 GU968258 GU968261 GU968267 GU968269 GU968273 GU968274 GU968279 GU968280 GU968281 GU968284 GU968285 GU968286 GU968289 GU968290 GU968295 GU968296 GU968298 GU968302 GU968305 GU968306 GU968307 GU968308 GU968315 GU968319 GU968322 GU968323 GU968329 GU968330 GU968332 GU968333 GU968334 GU968336 GU968337 GU968343 GU968344 GU968345 GU968348 GU968349 GU968352 GU968358 GU968362 GU968363 GU968364 GU968366 GU968367 GU968370 GU968371 GU968376 GU968378 GU968379 GU968380 GU968381 GU968382 GU968384 GU968385 GU968389 GU968396 GU968399 GU968400 GU968402 GU968404 GU968406 GU968410 GU968411 JFJJ01000011
SMR	Q2XU26
GO	GO:0015485 GO:0009405
Gene3D	3.90.840.10
InterPro	IPR001869
Pfam	PF01289
PRINTS	PR01400
SUPFAM	SSF56978
PROSITE	PS00481

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009405	pathogenesis	PMID:2731982	ECO:0000315			P		Figure 3. shows increased survival times for mice challenged with pneumolysin inactivated strains of S. pneumoniae.	complete CACAO 6002
involved_in	GO:0009405	pathogenesis	PMID:2731982	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001869 InterPro:IPR036359 InterPro:IPR036363	P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001869 InterPro:IPR036359 InterPro:IPR036363	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-1032	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
involved_in	GO:0044179	hemolysis in other organism	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0354	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0375	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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References

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