STRCO:TOP1

Species (Taxon ID)	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). (100226)
Gene Name(s)	topA (ECO:0000255 with HAMAP-Rule:MF_00952)
Protein Name(s)	DNA topoisomerase 1 (ECO:0000255 with HAMAP-Rule:MF_00952) DNA topoisomerase I (ECO:0000255 with HAMAP-Rule:MF_00952) Omega-protein Relaxing enzyme Swivelase Untwisting enzyme
External Links
UniProt	Q9X909
EMBL	AL939116
PIR	T36664
RefSeq	NP_627741.1 WP_011029075.1
ProteinModelPortal	Q9X909
SMR	Q9X909
STRING	100226.SCO3543
PRIDE	Q9X909
EnsemblBacteria	CAB38480
GeneID	1098979
KEGG	sco:SCO3543
PATRIC	fig|100226.15.peg.3599
eggNOG	ENOG4105C73 COG0550 COG1754
HOGENOM	HOG000004020
InParanoid	Q9X909
KO	K03168
OMA	IDFPGFF
OrthoDB	POG091H02BN
PhylomeDB	Q9X909
Proteomes	UP000001973
GO	GO:0003677 GO:0003917 GO:0046872 GO:0006265
CDD	cd00186 cd03363
Gene3D	1.10.290.10 1.10.460.10 2.70.20.10
HAMAP	MF_00952
InterPro	IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR013826 IPR023405 IPR003602 IPR005733 IPR028612 IPR025589 IPR006171 IPR034149
PANTHER	PTHR42785
Pfam	PF01131 PF01751 PF13368
PRINTS	PR00417
SMART	SM00437 SM00436 SM00493
SUPFAM	SSF56712
TIGRFAMs	TIGR01051
PROSITE	PS00396 PS50880

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007059	chromosome segregation	PMID:23913317	ECO:0000315			P		In figure 4, a wild type S. coelicolor (M145)and two examples of a mutant S. coelicolor without TopA proteins (PS01) were stained to show organization of cell walls (blue) and DNA (red) during sporulation. In the mutant cells, both the DNA and cell wall showed no order, as the red and blue colors were smeared throughout the cell. This meant that there is no chromosome condensing or separating. But in the wild type, the DNA is packed between evenly spaced cell walls. This means that, in the presence of TopA, chromosomes were condensed and segregated into different segments along the cell, ready for sporulation.	complete CACAO 13173
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000380 InterPro:IPR003601 InterPro:IPR003602 InterPro:IPR005733 InterPro:IPR013497 InterPro:IPR028612	F		Seeded From UniProt	complete
enables	GO:0003916	DNA topoisomerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003601 InterPro:IPR003602 InterPro:IPR013497 InterPro:IPR028612	F		Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000380 InterPro:IPR005733 InterPro:IPR023406	F		Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000380 InterPro:IPR003601 InterPro:IPR003602 InterPro:IPR005733 InterPro:IPR013497 InterPro:IPR028612	P		Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.99.1.2	F		Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106158	F		Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106158	P		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003916	DNA topoisomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0799	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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References

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