STRCO:CYC2

Species (Taxon ID)	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). (100226)
Gene Name(s)	cyc2
Protein Name(s)	Germacradienol/geosmin synthase Germacradienol/germacrene D synthase Sesquiterpene cyclase Sesquiterpene synthase Geosmin synthase
External Links
UniProt	Q9X839
EMBL	AL939126
PIR	T35865
RefSeq	NP_630182.1 WP_011030632.1
ProteinModelPortal	Q9X839
STRING	100226.SCO6073
EnsemblBacteria	CAB41566
GeneID	1101514
KEGG	sco:SCO6073
PATRIC	23742056
eggNOG	NOG15313
HOGENOM	HOG000253477
InParanoid	Q9X839
KO	K10187
OMA	IEMRRKV
OrthoDB	EOG622PK5
BioCyc	MetaCyc:MONOMER-14022
BRENDA	4.2.3.22
SABIO-RK	Q9X839
UniPathway	UPA00209 UPA00283 UPA00285
Proteomes	UP000001973
GO	GO:0034004 GO:0052577 GO:0000287
Gene3D	1.10.600.10
InterPro	IPR005630 IPR008949
Pfam	PF03936
SUPFAM	SSF48576

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0034004	germacradienol synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.3.22	F		Seeded From UniProt	complete
enables	GO:0052577	germacrene-D synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.3.22	F		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
	GO:0044550	secondary metabolite biosynthetic process	PMID:12563033	ECO:0006091	functional complementation evidence used in manual assertion		P		In this paper, the researchers used PCR targeting, gene replacement cassette, and transposon mutagenesis to determine whether genes cyc1 and cyc2 were both required for production of geosmin, a substance that gives soil its distinctive scent. GC-MS was used to detect geosmin production by each mutant. In Table 3, it is shown that when cyc2 is deleted, (strains J3001, J3002) there is no production of geosmin. When cyc1 is mutated using a transposon, geosmin is still produced. This indicates that cyc2, not cyc1, is required for the production of geosmin. To confirm this, the researchers reintroduced the cyc2 gene (complementation) via a vector into the strain, and geosmin production was restored.	complete CACAO 13559
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References

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