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STRAZ:Q8GGN5

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Species (Taxon ID) Streptomyces atroolivaceus. (66869)
Gene Name(s) LnmQ (ECO:0000313 with EMBL:AAN85530.1)
Protein Name(s) Nonribosomal peptide synthetase, discrete adenylation domain (ECO:0000313 with EMBL:AAN85530.1)
External Links
UniProt Q8GGN5
EMBL AF484556
ProteinModelPortal Q8GGN5
GO GO:0016874
InterPro IPR010071
IPR025110
IPR020845
IPR000873
Pfam PF00501
PF13193
TIGRFAMs TIGR01733
PROSITE PS00455

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0019184

nonribosomal peptide biosynthetic process

PMID:15112993[1]

ECO:0000315

P

Fig. 4B shows HPLC analysis of the formation of leinamycin. Mutants lacking lnmQ don't produce leinamycin.

complete
CACAO 10755

GO:0043042

amino acid adenylylation by nonribosomal peptide synthase

PMID:17502372[2]

ECO:0000314

P

Fig. 2 shows the amino acid specificity and Michaelis-Menton kinetics of LnmQ.

complete
CACAO 10756

involved_in

GO:0043042

amino acid adenylylation by nonribosomal peptide synthase

PMID:17502372[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000873

F

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Tang, GL et al. (2004) Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chem. Biol. 11 33-45 PubMed GONUTS page
  2. 2.0 2.1 Tang, GL et al. (2007) Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine. J. Biol. Chem. 282 20273-82 PubMed GONUTS page